Document Detail

Clearance of maternal isohemagglutinins from infant circulation (CME).
MedLine Citation:
PMID:  20977483     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Non-group O neonates require testing for passively acquired maternal isohemagglutinins for them to receive type-specific red blood cells (RBCs), according to the latest edition of the AABB Standards. A neonate is defined as an infant up to 4 months old in the AABB Standards, and many blood banks tend to stop testing for maternal anti-A and/or anti-B after 4 months of age. In lieu of such testing, group O RBCs are usually transfused to infants up to 4 months of age. This practice can limit the overall supply of group O RBCs available to other patients.
STUDY DESIGN AND METHODS: A retrospective study of 1309 infants up to 4 months of age was performed, to assess the age by which passively acquired maternal isohemagglutinins are cleared from infant circulation. Detection of isohemagglutinins was performed by mixing sample sera and observing agglutination, followed by incubation and addition of anti-immunoglobulin anti-human globulin (antiglobulin test phase).
RESULTS: The data show that 6.4% of infants up to 1 month of age had maternal isohemagglutinins, while none of the infants ranging from 2 to 4 months of age had maternal isohemagglutinins in their sera.
CONCLUSIONS: Maternal isohemagglutinins are rare after the first month of life and patients who are at least 2 months old can safely receive ABO type-compatible RBC units without testing for passively acquired maternal anti-A and/or anti-B.
Salima Shaikh; Steven R Sloan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-26
Journal Detail:
Title:  Transfusion     Volume:  51     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-06     Completed Date:  2011-07-12     Revised Date:  2012-02-16    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  938-42     Citation Subset:  IM    
Copyright Information:
© 2010 American Association of Blood Banks.
Department of Pathology, Division of Transfusion Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
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MeSH Terms
ABO Blood-Group System / immunology*
Age Factors
Blood Banks / methods
Blood Grouping and Crossmatching / methods*
Blood Transfusion
Erythrocytes / immunology
Hemagglutinins / blood*,  immunology*
Immunity, Maternally-Acquired / immunology*
Infant, Newborn
Organizational Policy
Retrospective Studies
Grant Support
5T32HL066987-10/HL/NHLBI NIH HHS
Reg. No./Substance:
0/ABO Blood-Group System; 0/Hemagglutinins
Comment In:
Transfusion. 2012 Feb;52(2):455; author reply 455-6   [PMID:  22239214 ]
Transfusion. 2011 May;51(5):908-13   [PMID:  21545590 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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