| Clearance of chylomicron remnants in normolipidaemic patients with coronary artery disease: case control study over three years. | |
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MedLine Citation:
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PMID: 8616304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the hypothesis that subjects who clear chylomicron remnants slowly from plasma may be at higher risk of coronary artery disease than indicated by their fasting plasma lipid concentrations. DESIGN: Case control study over three years. SETTING: An 800 bed general municipal hospital. SUBJECTS: 85 normolipidaemic patients with coronary artery disease selected prospectively and matched with 85 normolipidaemic subjects with normal coronary arteries on angiography. INTERVENTIONS: All subjects were given a vitamin A fat loading test which specifically labels intestinal lipoproteins with retinyl palmitate. MAIN OUTCOME MEASURE: Postprandial lipoprotein metabolism. RESULTS: The area below the chylomicron remnant retinyl palmitate curve was significantly increased in the coronary artery disease group as compared with the controls (mean 23.4 (SD 15.0) v 15.3 (8.9) mumol/l.h; 95% confidence interval of difference 4.37 to 11.82). CONCLUSION: Normolipidaemic patients with coronary artery disease had significantly higher concentrations of chylomicron remnants in plasma than normolipidaemic subjects with normal coronary vessels. This may explain the mechanism underlying the susceptibility to atherosclerosis of coronary artery disease patients with normal fasting lipid values. As diet and drugs can ameliorate the accumulation of postprandial lipoproteins in plasma, the concentration of chylomicron remnants should be measured in patients at high risk of coronary artery disease. |
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Authors:
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M S Weintraub; I Grosskopf; T Rassin; H Miller; G Charach; H H Rotmensch; M Liron; A Rubinstein; A Iaina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: BMJ (Clinical research ed.) Volume: 312 ISSN: 0959-8138 ISO Abbreviation: BMJ Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-06-07 Completed Date: 1996-06-07 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 8900488 Medline TA: BMJ Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 935-9 Citation Subset: AIM; IM |
Affiliation:
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Tel Aviv-Sourasky Medical Center, Tel Aviv University, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Chylomicrons / blood, metabolism* Coronary Disease / etiology*, metabolism Dietary Fats / diagnostic use Female Humans Lipids / blood* Lipoproteins / metabolism Male Middle Aged Prospective Studies Triglycerides / metabolism Vitamin A / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dietary Fats; 0/Lipids; 0/Lipoproteins; 0/Triglycerides; 11103-57-4/Vitamin A |
| Comments/Corrections | |
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