| Clearance and beyond: the complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI). | |
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MedLine Citation:
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PMID: 21753074 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acute kidney injury (AKI) is a common and frequently fatal illness in critically ill patients. The reliance on serum creatinine as a surrogate of GFR not only delays diagnosis and development of successful therapies, but also hinders insight into the pathophysiology of human AKI. Measurement of GFR under non-steady state conditions remains an elusive gold standard against which biomarkers of renal injury need to be judged. Approaches to the rapid (near real-time) measurement of GFR are explored. Even if real-time GFR was available, absent baseline information will always limit diagnosis of AKI based on GFR or serum creatinine to a detection of change. Biomarkers of renal cellular injury have provided new strategies to facilitate detection and early intervention in AKI. However, the diagnostic and predictive performance of urinary biomarkers of injury vary, depending on both the time after renal injury and on the pre-injury GFR. Progress in understanding the role of each novel biomarker in the causal pathways of AKI promises to enhance their diagnostic potential. We predict that combining rapid measures of GFR with biomarkers of renal injury will yield substantive progress in the treatment of AKI. |
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Authors:
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Zoltan H Endre; John W Pickering; Robert J Walker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-13 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: - ISSN: 1522-1466 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Otago, Christchurch. |
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