Document Detail

Clearance of 99mTc-DTPA and experimentally increased alveolar surfactant content.
MedLine Citation:
PMID:  1592733     Owner:  NLM     Status:  MEDLINE    
We measured clearance of 99mTc-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) in rabbits with experimentally increased alveolar surfactant content. In one group of animals, surfactant production was increased by treatment with ambroxol, and another group of animals was treated with tracheal instillation of natural surfactant. A group of untreated control animals and animals treated with instillation of saline were also studied. Clearance was measured during standard conditions of mechanical ventilation and during ventilation with large tidal volumes. In ambroxol- and surfactant-treated groups, clearance rate was reduced compared with untreated control animals. In contrast, clearance rate increased after saline instillation. The differences were observed at both modes of ventilation. The findings indicate that the pulmonary surfactant system is a rate-limiting factor for the clearance of 99mTc-DTPA and that the volume dependence of clearance is not explained by stretching of the alveolar wall only.
J A Bos; P Wollmer; W Bakker; E Hannappel; B Lachmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  72     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1413-7     Citation Subset:  IM    
Department of Anaesthesiology, Erasmus University, Rotterdam, The Netherlands.
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MeSH Terms
Ambroxol / pharmacology
Metabolic Clearance Rate
Pulmonary Alveoli / drug effects,  metabolism*
Pulmonary Surfactants / metabolism*
Respiration, Artificial
Technetium Tc 99m Pentetate / pharmacokinetics*
Tidal Volume / physiology
Reg. No./Substance:
0/Pulmonary Surfactants; 18683-91-5/Ambroxol; 65454-61-7/Technetium Tc 99m Pentetate

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