Document Detail

Clear cell endocrine tumor of the pancreas which is not associated with von Hippel-Lindau disease: report of a case.
MedLine Citation:
PMID:  12768377     Owner:  NLM     Status:  MEDLINE    
We describe the case of a pancreatic endocrine tumor with marked clear cell changes. The patient, a 56-year-old woman, presented with appetite loss and nausea but no evidence of either von Hippel-Lindau disease, or a family history of the disease. A radiological examination revealed a hypervascular tumor measuring 5.2 cm in diameter located in the pancreatic head. The patient underwent a pylorus-preserving pancreatoduodenectomy. The cut surface of the tumor was yellowish and well demarcated. Histologically, the tumor was composed of cuboidal cells with clear cytoplasm, thus forming trabecular and insular nests. Immunohistochemically, the tumor cells were strongly positive for chromogranin. An electron microscopic examination revealed the tumor cells to contain neuroendocrine secretory granules, abundant lipid droplets, and some crystalloid bodies in the cytoplasm. We conclusively diagnosed it to be a pancreatic clear cell endocrine tumor. Such tumors not associated with von Hippel-Lindau disease are extremely rare.
Souya Nunobe; Noriyoshi Fukushima; Shinichi Yachida; Kazuaki Shimada; Tomoo Kosuge; Michiie Sakamoto
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery today     Volume:  33     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2003  
Date Detail:
Created Date:  2003-05-27     Completed Date:  2003-09-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  470-4     Citation Subset:  IM    
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
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MeSH Terms
Carcinoma, Islet Cell / diagnosis*,  pathology
Diagnosis, Differential
Middle Aged
Pancreatic Neoplasms / diagnosis*,  pathology
von Hippel-Lindau Disease / diagnosis*

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