Document Detail

Clear cell carcinoma: review of its histomorphogenesis and classification as a squamous cell lesion.
MedLine Citation:
PMID:  19570692     Owner:  NLM     Status:  MEDLINE    
In current classification schemes, clear cell carcinoma-including both the hyalinized and nonhyalinized variety--is now an accepted subtype of malignant salivary gland tumors. Despite this, the underlying cellular differentiation process leading to the typical histomorphology of this neoplasm remains unclear. This review summarizes and illustrates the histologic, ultrastructural, and immunohistochemical evidence for the underlying squamous cell nature of clear cell carcinoma. Squamous cell differentiation is not an uncommon feature of nonneoplastic and neoplastic lesions of the salivary glands. Clear cell carcinoma needs to be added to this list as a unique but specific variety of clear cell squamous carcinoma.
Irving Dardick; Iona Leong
Publication Detail:
Type:  Journal Article; Review     Date:  2009-07-01
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  108     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-31     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-405     Citation Subset:  D; IM    
Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario.
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MeSH Terms
Adenocarcinoma, Clear Cell / classification,  pathology*,  ultrastructure
Carcinoma, Squamous Cell / classification,  pathology
Cell Differentiation
Epithelial Cells / pathology,  ultrastructure
Salivary Gland Neoplasms / classification,  pathology*,  ultrastructure

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