Document Detail

Clear cell adenocarcinoma of the vagina in a young female, treated by combination chemotherapy (local and systemic chemotherapy), complicated with chromosomal abnormality.
MedLine Citation:
PMID:  7959294     Owner:  NLM     Status:  MEDLINE    
Although cancer of the vagina, a rare form of genital cancer, is usually squamous cell carcinoma in women over the age of 50 years, vaginal clear cell adenocarcinomas (CCA) are exceedingly rare. The pathogenesis of clear cell adenocarcinoma is uncertain, but as a clinical entity, it is most commonly associated with diethylstilbestrol exposure in utero. We report a rare case of primary vaginal CCA in a 17-year-old female who was not exposed to diethylstilbesterol in utero. The case, which was complicated with chromosomal abnormality, was treated with combination chemotherapy. To our knowledge, this is the first reported case of vaginal CCA in a woman with chromosomal abnormality and bicornate uterus.
H Tanaka; T Tabata; H Yanase; M Nishiyama; T Yamawaki; H Taniguchi; N Toyoda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  55     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-27     Completed Date:  1994-12-27     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Department of Gynecology and Obstetrics, Mie University School of Medicine, Japan.
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MeSH Terms
Adenocarcinoma, Clear Cell / complications,  drug therapy*,  genetics*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Chromosome Aberrations*
Chromosome Disorders*
Cisplatin / administration & dosage
Cyclophosphamide / administration & dosage
DNA, Neoplasm / genetics
Diethylstilbestrol / adverse effects
Doxorubicin / administration & dosage
Prenatal Exposure Delayed Effects
Uterus / abnormalities
Vaginal Neoplasms / complications,  drug therapy*,  genetics*
X Chromosome
Reg. No./Substance:
0/DNA, Neoplasm; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 56-53-1/Diethylstilbestrol

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