| Clear cell adenocarcinoma of the vagina in a young female, treated by combination chemotherapy (local and systemic chemotherapy), complicated with chromosomal abnormality. | |
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MedLine Citation:
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PMID: 7959294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although cancer of the vagina, a rare form of genital cancer, is usually squamous cell carcinoma in women over the age of 50 years, vaginal clear cell adenocarcinomas (CCA) are exceedingly rare. The pathogenesis of clear cell adenocarcinoma is uncertain, but as a clinical entity, it is most commonly associated with diethylstilbestrol exposure in utero. We report a rare case of primary vaginal CCA in a 17-year-old female who was not exposed to diethylstilbesterol in utero. The case, which was complicated with chromosomal abnormality, was treated with combination chemotherapy. To our knowledge, this is the first reported case of vaginal CCA in a woman with chromosomal abnormality and bicornate uterus. |
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Authors:
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H Tanaka; T Tabata; H Yanase; M Nishiyama; T Yamawaki; H Taniguchi; N Toyoda |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gynecologic oncology Volume: 55 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-27 Completed Date: 1994-12-27 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 259-64 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, Mie University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Clear Cell
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complications,
drug therapy*,
genetics* Adolescent Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Chromosome Aberrations* Chromosome Disorders* Cisplatin / administration & dosage Cyclophosphamide / administration & dosage DNA, Neoplasm / genetics Diethylstilbestrol / adverse effects Doxorubicin / administration & dosage Female Humans Karyotyping Pregnancy Prenatal Exposure Delayed Effects Uterus / abnormalities Vaginal Neoplasms / complications, drug therapy*, genetics* X Chromosome |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 56-53-1/Diethylstilbestrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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