Document Detail

Clear cell adenocarcinoma of the vagina in a patient with vaginal endometriosis.
MedLine Citation:
PMID:  16996119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Malignant transformation of endometriosis is an infrequent complication of endometriosis. Extragonadal disease is uncommon. CASE: 55-year-old female presented with postmenopausal bleeding. Physical examination revealed a 2-cm polypoid lesion at the posterior vaginal apex, which was found to be a moderately differentiated invasive adenocarcinoma. Final pathology at the time of definitive surgery demonstrated a clear cell adenocarcinoma of the vagina arising in vaginal endometriosis. CONCLUSION: Vaginal endometriosis may lead to the development of cancer. Malignancy arising in endometriotic foci is rare, but most commonly occurs in the ovary. We report a case of clear cell malignancy arising in vaginal endometriosis, adding to only seven cases previously reported. Risk factors include unopposed estrogen and obesity, but it may occur in the absence of either.
Chirag Shah; Ellen Pizer; Dan S Veljovich; Charles W Drescher; William A Peters; Pamela J Paley
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-09-22
Journal Detail:
Title:  Gynecologic oncology     Volume:  103     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1130-2     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Washington Medical Center, Box 356460, Seattle, WA 98195-6460, USA.
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MeSH Terms
Adenocarcinoma, Clear Cell / complications,  diagnosis*,  pathology,  surgery
Diagnosis, Differential
Endometriosis / complications,  diagnosis*,  pathology,  surgery
Middle Aged
Vaginal Neoplasms / complications,  diagnosis*,  pathology,  surgery

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