Document Detail


A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination.
MedLine Citation:
PMID:  20651376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical studies of WT1-targeted cancer vaccine are being performed. However, WT1-specific Th response in cancer patients remains unclear. Using quantitative real-time RT-PCR, we investigated IFN-gamma and IL-10 mRNA expression from Th cells by stimulation with helper peptide WT1(332). Seventeen patients, of whom 10 had achieved stable disease and the remaining 7 had progressive disease, were weekly vaccinated with WT1 CTL epitope (modified WT1(235)) and examined for WT1(332)-specific Th response. A clear correlation between WT1(332)-specific Th response and clinical response was observed at 4 weeks post-vaccination. In patients who responded, a clear inverse correlation between IL-10-type and IFN-gamma-type WT1(332)-specific Th response was detected at pre- and 4 weeks post-vaccination, and the shift of the Th response from IL-10-type dominancy at early phase to IFN-gamma-type dominancy at late phase was observed. From this study we concluded that occurrence of WT1(332)-specific Th response could predict good clinical response of WT1 CTL epitope vaccination.
Authors:
Fumihiro Fujiki; Yoshihiro Oka; Mai Kawakatsu; Akihiro Tsuboi; Yukie Tanaka-Harada; Naoki Hosen; Sumiyuki Nishida; Toshiaki Shirakata; Hiroko Nakajima; Naoya Tatsumi; Naoya Hashimoto; Tetsuya Taguchi; Satsuki Ueda; Norio Nonomura; Yutaka Takeda; Toshinori Ito; Akira Myoui; Shuichi Izumoto; Motohiko Maruno; Toshiki Yoshimine; Shinzaburo Noguchi; Akihiko Okuyama; Ichiro Kawase; Yusuke Oji; Haruo Sugiyama
Related Documents :
16709246 - The continuing hiv vaccine saga: is a paradigm shift necessary?
20156506 - Identification of broad binding class i hla supertype epitopes to provide universal cov...
21991446 - Immunogenicity studies in carnivores using a rabies virus construct with a site-directe...
22205966 - Polyvalent dna vaccines expressing ha antigens of h5n1 influenza viruses with an optimi...
19007836 - Efficacy of bp26 and bp26/omp31 b. melitensis rev.1 deletion mutants against brucella o...
21316456 - Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2247-54     Citation Subset:  IM    
Affiliation:
Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 1-7, Yamada-Oka, Suita City, Osaka 565-0871, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cancer Vaccines / immunology*
Epitopes, T-Lymphocyte*
Female
Humans
Interferon-gamma / genetics
Interleukin-10 / genetics
Male
Middle Aged
RNA, Messenger / analysis
T-Lymphocytes, Cytotoxic / immunology*
T-Lymphocytes, Helper-Inducer / immunology*
Vaccination*
WT1 Proteins / immunology*
Chemical
Reg. No./Substance:
0/Cancer Vaccines; 0/Epitopes, T-Lymphocyte; 0/RNA, Messenger; 0/WT1 Proteins; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sonodynamically Induced Cell Damage and Membrane Lipid Peroxidation by Novel Porphyrin Derivative, D...
Next Document:  Phase I study of oral vinorelbine and capecitabine in patients with metastatic breast cancer.