| A clear correlation between WT1-specific Th response and clinical response in WT1 CTL epitope vaccination. | |
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MedLine Citation:
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PMID: 20651376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical studies of WT1-targeted cancer vaccine are being performed. However, WT1-specific Th response in cancer patients remains unclear. Using quantitative real-time RT-PCR, we investigated IFN-gamma and IL-10 mRNA expression from Th cells by stimulation with helper peptide WT1(332). Seventeen patients, of whom 10 had achieved stable disease and the remaining 7 had progressive disease, were weekly vaccinated with WT1 CTL epitope (modified WT1(235)) and examined for WT1(332)-specific Th response. A clear correlation between WT1(332)-specific Th response and clinical response was observed at 4 weeks post-vaccination. In patients who responded, a clear inverse correlation between IL-10-type and IFN-gamma-type WT1(332)-specific Th response was detected at pre- and 4 weeks post-vaccination, and the shift of the Th response from IL-10-type dominancy at early phase to IFN-gamma-type dominancy at late phase was observed. From this study we concluded that occurrence of WT1(332)-specific Th response could predict good clinical response of WT1 CTL epitope vaccination. |
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Authors:
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Fumihiro Fujiki; Yoshihiro Oka; Mai Kawakatsu; Akihiro Tsuboi; Yukie Tanaka-Harada; Naoki Hosen; Sumiyuki Nishida; Toshiaki Shirakata; Hiroko Nakajima; Naoya Tatsumi; Naoya Hashimoto; Tetsuya Taguchi; Satsuki Ueda; Norio Nonomura; Yutaka Takeda; Toshinori Ito; Akira Myoui; Shuichi Izumoto; Motohiko Maruno; Toshiki Yoshimine; Shinzaburo Noguchi; Akihiko Okuyama; Ichiro Kawase; Yusuke Oji; Haruo Sugiyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2247-54 Citation Subset: IM |
Affiliation:
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Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 1-7, Yamada-Oka, Suita City, Osaka 565-0871, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cancer Vaccines / immunology* Epitopes, T-Lymphocyte* Female Humans Interferon-gamma / genetics Interleukin-10 / genetics Male Middle Aged RNA, Messenger / analysis T-Lymphocytes, Cytotoxic / immunology* T-Lymphocytes, Helper-Inducer / immunology* Vaccination* WT1 Proteins / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cancer Vaccines; 0/Epitopes, T-Lymphocyte; 0/RNA, Messenger; 0/WT1 Proteins; 130068-27-8/Interleukin-10; 82115-62-6/Interferon-gamma |
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