| Clay ingestion enhances intestinal triacylglycerol hydrolysis and non-esterified fatty acid absorption. | |
| | |
MedLine Citation:
|
PMID: 19138447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Consumption by animals and humans of earthy materials such as clay is often related to gut pathologies. Our aim was to determine the impact of kaolinite ingestion on glucose and NEFA transport through the intestinal mucosa. The expression of hexose transporters (Na/glucose co-transporter 1 (SGLT1), GLUT2, GLUT5) and of proteins involved in NEFA absorption (fatty acid transporter/cluster of differentiation 36 (FAT/CD36), fatty acid transport protein 4 (FATP4) and liver fatty acid binding protein (L-FABP)) was measured (1) in rats whose jejunum was perfused with a solution of kaolinite, and (2) in rats who ate spontaneously kaolinite pellets during 7 and 28 d. Also, we determined TAG and glucose absorption in the kaolinite-perfused group, and pancreatic lipase activity, gastric emptying and intestinal transit in rats orally administered with kaolinite. Glucose absorption was not affected by kaolinite perfusion or ingestion. However, kaolinite induced a significant increase in intestinal TAG hydrolysis and NEFA absorption. The cytoplasmic expression of L-FABP and FATP4 also increased due to kaolinite ingestion. NEFA may enter the enterocytes via endocytosis mainly since expression of NEFA transporters in the brush-border membrane was not affected by kaolinite. After uptake, rapid binding of NEFA by L-FABP and FATP4 could act as an intracellular NEFA buffer to prevent NEFA efflux. Increased TAG hydrolysis and NEFA absorption may be due to the adsorption properties of clay and also because kaolinite ingestion caused a slowing down of gastric emptying and intestinal transit. |
| | |
Authors:
|
Caroline Habold; François Reichardt; Yvon Le Maho; Fabielle Angel; Nicole Liewig; Jean-Hervé Lignot; Hugues Oudart |
Related Documents
:
|
6707197 - An evaluation of the importance of gastric acid secretion in the absorption of dietary ... 8125387 - Effects of short chain fatty acids on gut morphology and function. 11510947 - Short-chain fatty acids enhance diffusional ca transport in the epithelium of the rat c... 304877 - Characterization of p-aminobenzoic acid transport across the rat intestine. 16656387 - Amino acid and protein metabolism in bermuda grass during water stress. 1156557 - A study of chemical light screening agents. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-13 |
Journal Detail:
|
Title: The British journal of nutrition Volume: 102 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-07-09 Completed Date: 2009-09-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 249-57 Citation Subset: IM |
Affiliation:
|
Institut Pluridisciplinaire Hubert Curien, UMR 7178 CNRS-ULP, 23 Rue du Loess, BP28, 67037 Strasbourg Cedex 2, France. caroline.habold@c-strasbourg.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Antidiarrheals / administration & dosage* Fatty Acid Transport Proteins / genetics Fatty Acid-Binding Proteins / genetics Fatty Acids, Nonesterified / metabolism* Gastric Emptying / physiology Gastrointestinal Transit Glucose / metabolism Glucose Transporter Type 5 / genetics Hydrolysis Intestinal Absorption / physiology* Intestines / metabolism* Kaolin / administration & dosage* Lipase / analysis Male RNA, Messenger / analysis Rats Rats, Wistar Sodium-Glucose Transporter 1 / genetics Triglycerides / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Antidiarrheals; 0/FATP4 protein, rat; 0/Fatty Acid Transport Proteins; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids, Nonesterified; 0/Glucose Transporter Type 5; 0/RNA, Messenger; 0/Sodium-Glucose Transporter 1; 0/Triglycerides; 1332-58-7/Kaolin; 50-99-7/Glucose; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Geographic variation in the prevalence of overweight and economic status in Chinese adults.
Next Document: Replacing foods high in saturated fat by low-saturated fat alternatives: a computer simulation of th...