Document Detail

Clavulanic acid biosynthesis and genetic manipulation for its overproduction.
MedLine Citation:
PMID:  20711575     Owner:  NLM     Status:  MEDLINE    
Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained.
Ju Yeon Song; Susan E Jensen; Kye Joon Lee
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-08-14
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  88     ISSN:  1432-0614     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  659-69     Citation Subset:  IM    
School of Biological Sciences, Seoul National University, Seoul 151-747, South Korea.
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MeSH Terms
Anti-Bacterial Agents / biosynthesis*
Clavulanic Acid / biosynthesis*
Clavulanic Acids / biosynthesis*
Genes, Bacterial
Genetic Engineering / methods*
Molecular Structure
Multigene Family
Streptomyces / genetics*,  metabolism
beta-Lactamases / biosynthesis,  genetics
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Clavulanic Acids; 0/clavam; 58001-44-8/Clavulanic Acid; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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