| Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumor-elicited macrophages in vivo. | |
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MedLine Citation:
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PMID: 22268650 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Macrophages altered by various Th2-associated and anti-inflammatory mediators - including IL-4 and IL-13 (inducing alternatively activated macrophages [AAMs]), IL-10 and TGF-β - were generically termed M2. However, markers which discriminate between AAMs and other M2 remain scarce. We previously described E-cadherin as a marker for AAMs, permitting these macrophages to fuse upon IL-4 stimulation. In order to identify novel potential contributors to macrophage fusion, we assessed the effect of IL-4 on other adherens and tight junction-associated components. We observed an induction of claudin-1 (Cldn1), Cldn2 and Cldn11 genes by IL-4 in different mouse macrophage populations. Extending our findings to other stimuli revealed Cldn1 as a mainly TGF-β-induced gene and showed that Cldn11 is predominantly associated with IL-4-induced AAMs. Cldn2 is upregulated by diverse stimuli and is not associated with a specific macrophage activation state in vitro. Interestingly, different claudin genes preferentially associate with M2 from distinct diseases. While Cldn11 is predominantly expressed in AAMs from helminth infected mice, Cldn1 is the major macrophage claudin during chronic trypanosomiasis and Cldn2 dominates in tumor-associated macrophages. Overall, we identified Cldn1, Cldn2 and Cldn11 as genes which discriminate between diverse types of M2. |
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Authors:
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Jan Van den Bossche; Damya Laoui; Yannick Morias; Kiavash Movahedi; Geert Raes; Patrick De Baetselier; Jo A Van Ginderachter |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: - ISSN: 1365-3083 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Scandinavian Journal of Immunology © 2012 Blackwell Publishing Ltd. |
Affiliation:
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Myeloid Cell Immunology Laboratory, VIB, Brussels, Belgium Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium. |
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