| Claudication: exercise vs endoluminal revascularization (CLEVER) study update. | |
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MedLine Citation:
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PMID: 19660897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Claudication: Exercise vs Endoluminal Revascularization (CLEVER) Study is a prospective multicenter randomized clinical trial designed to compare the relative clinical and cost-effectiveness of invasive revascularization with stents to supervised exercise rehabilitation in a cohort with moderate to severe claudication due to aortoiliac insufficiency. The study is currently enrolling at twenty-eight sites in the US and Canada. Enrollment of 217 participants is planned, with data collected at baseline, six months, and 18 months. The primary study endpoint is maximum walking duration (MWD) on a graded treadmill test; secondary endpoints include community-based walking, markers of cardiovascular disease risk (body mass index, waist circumference, blood pressure, lipid profile, glucose tolerance, and plasma fibrinogen), health-related quality of life, and cost effectiveness. There are currently sixty randomized participants; recruitment is projected to end in July 2010 and final study results reported in June 2012. |
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Authors:
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Timothy P Murphy; Alan T Hirsch; Donald E Cutlip; Judith G Regensteiner; Anthony J Comerota; Emile Mohler; David J Cohen; Joseph Massaro; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-08-05 |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 50 ISSN: 1097-6809 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-29 Completed Date: 2009-10-15 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 942-945.e2 Citation Subset: IM |
Affiliation:
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Rhode Island Hospital Vascular Disease Research Center and Brown Medical School Department of Diagnostic Imaging, Providence, RI 02903, USA. tmurphy@lifespan.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty
/
economics,
methods* Cost of Illness Cost-Benefit Analysis Double-Blind Method Exercise* Exercise Test* Female Follow-Up Studies Humans Intermittent Claudication / economics, rehabilitation*, surgery* Male Prospective Studies Risk Assessment Severity of Illness Index Treatment Outcome United States |
| Grant Support | |
ID/Acronym/Agency:
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U01 HL077221/HL/NHLBI NIH HHS; U01 HL077221-01A1/HL/NHLBI NIH HHS; U01 HL077221-02/HL/NHLBI NIH HHS; U01 HL077221-03/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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J Vasc Surg. 2009 Oct;50(4):945
[PMID:
19786243
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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