Document Detail


Claudication: exercise vs endoluminal revascularization (CLEVER) study update.
MedLine Citation:
PMID:  19660897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Claudication: Exercise vs Endoluminal Revascularization (CLEVER) Study is a prospective multicenter randomized clinical trial designed to compare the relative clinical and cost-effectiveness of invasive revascularization with stents to supervised exercise rehabilitation in a cohort with moderate to severe claudication due to aortoiliac insufficiency. The study is currently enrolling at twenty-eight sites in the US and Canada. Enrollment of 217 participants is planned, with data collected at baseline, six months, and 18 months. The primary study endpoint is maximum walking duration (MWD) on a graded treadmill test; secondary endpoints include community-based walking, markers of cardiovascular disease risk (body mass index, waist circumference, blood pressure, lipid profile, glucose tolerance, and plasma fibrinogen), health-related quality of life, and cost effectiveness. There are currently sixty randomized participants; recruitment is projected to end in July 2010 and final study results reported in June 2012.
Authors:
Timothy P Murphy; Alan T Hirsch; Donald E Cutlip; Judith G Regensteiner; Anthony J Comerota; Emile Mohler; David J Cohen; Joseph Massaro;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-08-05
Journal Detail:
Title:  Journal of vascular surgery     Volume:  50     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-29     Completed Date:  2009-10-15     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  942-945.e2     Citation Subset:  IM    
Affiliation:
Rhode Island Hospital Vascular Disease Research Center and Brown Medical School Department of Diagnostic Imaging, Providence, RI 02903, USA. tmurphy@lifespan.org
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MeSH Terms
Descriptor/Qualifier:
Angioplasty / economics,  methods*
Cost of Illness
Cost-Benefit Analysis
Double-Blind Method
Exercise*
Exercise Test*
Female
Follow-Up Studies
Humans
Intermittent Claudication / economics,  rehabilitation*,  surgery*
Male
Prospective Studies
Risk Assessment
Severity of Illness Index
Treatment Outcome
United States
Grant Support
ID/Acronym/Agency:
U01 HL077221/HL/NHLBI NIH HHS; U01 HL077221-01A1/HL/NHLBI NIH HHS; U01 HL077221-02/HL/NHLBI NIH HHS; U01 HL077221-03/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
J Vasc Surg. 2009 Oct;50(4):945   [PMID:  19786243 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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