| Clastogenic plasma factors: a short overview. | |
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MedLine Citation:
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PMID: 20020152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A large number of studies have revealed that irradiated subjects produce soluble factors found in their blood plasma which, when transferred into cell cultures from non-irradiated individuals, show clastogenic (chromosome breaking) activity. Increased yields of chromatid-type aberrations have been characteristic in most of these studies. Exposed cohorts of various origins have revealed to possess this feature: from A-bomb survivors to patients treated with radiotherapy. It is apparent that the plasma factors are sustainable for long time periods. On the other hand, they seem to be produced very fast after exposure. Considerable variation in the effect has been found between individuals with similar radiation exposure. Further, the phenomenon is not restricted to irradiated populations. Clastogenic plasma has also been observed in patients with inflammatory diseases or congenital chromosome breakage syndromes as well in subjects exposed to other agents than ionizing radiation. Chromosomal aberration inducing substances have been detected not only in vivo, but also in vitro. A common feature to all the conditions is that they are associated with oxidative stress. Studies on the biochemical nature of the clastogenic factor(s) have been conducted, and tumor necrosis factor alpha and lipid peroxidation products, among others, have been suggested as good candidates. The relevance of the plasma factors to health effects remains open. The aim of the paper is to give a short overview on the phenomenon of clastogenic factors--their occurrence and formation as well as possible effectors. |
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Authors:
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Carita Lindholm; Anna Acheva; Sisko Salomaa |
Publication Detail:
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Type: Journal Article; Review Date: 2009-12-18 |
Journal Detail:
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Title: Radiation and environmental biophysics Volume: 49 ISSN: 1432-2099 ISO Abbreviation: Radiat Environ Biophys Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415677 Medline TA: Radiat Environ Biophys Country: Germany |
Other Details:
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Languages: eng Pagination: 133-8 Citation Subset: IM |
Affiliation:
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Radiation and Nuclear Safety Authority (STUK), P.O. Box 14, 00881, Helsinki, Finland. carita.lindholm@stuk.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Factors / biosynthesis, chemistry, metabolism*, pharmacology Chromosome Aberrations / chemically induced, radiation effects Chromosome Breakage / radiation effects* Cohort Studies Humans Inflammation / blood, genetics Plasma / chemistry, metabolism*, radiation effects* |
| Chemical | |
Reg. No./Substance:
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0/Biological Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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