| Classifying the severity of corneal ulcers by using the "1, 2, 3" rule. | |
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MedLine Citation:
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PMID: 17198008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To propose and define the "1, 2, 3" rule as a system of categorizing the severity of bacterial keratitis and to determine its value in predicting the likelihood of visual loss after healing of bacterial corneal infection. METHODS: Seventy patients were evaluated for infectious corneal ulcers by 2 cornea subspecialists (J.D.L., M.C.V.) at a tertiary facility between October 30, 2001, and November 1, 2004. Forty-one patients met the inclusion criteria. Visual acuities, ulcer characteristics, culture results, and treatment data were collected. RESULTS: The sensitivity of the "1, 2, 3" rule for detecting potentially sight-threatening (PST) ulcers that would result in 0.20 logMAR (2 Snellen lines) or greater loss in best spectacle-corrected visual acuity (BSCVA) was 100%. The specificity of the "1, 2, 3" rule in correctly labeling an ulcer that did not cause vision loss as rarely sight threatening (RST) was 57.14%. The positive predictive value of the "1, 2, 3" rule was 28.57%. The negative predictive value of the "1, 2, 3" rule was 100%. CONCLUSIONS: Corneal ulcers classified as PST are at significantly higher risk for sustaining loss of BCSVA compared with RST corneal ulcers. The "1, 2, 3" rule is sensitive and specific enough to be clinically useful in predicting which ulcers are more likely to have vision loss and which ulcers are not. |
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Authors:
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Mark C Vital; Marcel Belloso; Thomas C Prager; Jeffrey D Lanier |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-01 Completed Date: 2007-02-20 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Affiliation:
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Houston Eye Associates, Houston, TX, USA. mceyemd@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents / therapeutic use Corneal Ulcer / classification*, drug therapy, microbiology* Diagnostic Techniques, Ophthalmological* Eye Infections, Bacterial / classification*, drug therapy, microbiology False Positive Reactions Female Humans Likelihood Functions Male Middle Aged Predictive Value of Tests Risk Factors Sensitivity and Specificity Severity of Illness Index Vancomycin / therapeutic use Vision Disorders / etiology Wound Healing |
| Grant Support | |
ID/Acronym/Agency:
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EY10608/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 1404-90-6/Vancomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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