Document Detail


Classifying lower limb dynamics in Parkinson's disease.
MedLine Citation:
PMID:  12832009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To classify lower limb dynamics in patients with Parkinson's disease (PD), we conducted a clinical study by using pedaling exercise.Twenty-seven patients with idiopathic PD were included in this study. We measured rotational velocities of pedals during pedaling movements with a newly developed ergometer. The velocity waveforms exhibited different characteristics among patients, which could be categorized into four different clusters. In cluster 1, the amplitude on each side was constant and the relative phase was locked at 180 degrees. The pattern was the same as seen in normal subjects. In cluster 2, the amplitude on each side was constant, but the relative phase was locked at 90 degrees. In cluster 3, the amplitude on each side was modulated, and the relative phase drifted monotonously from 0 to 360 degrees during pedaling cycles. In cluster 4, the amplitude on each side was synchronously and irregularly modulated, and the relative phase fluctuated with intermittent spike-like decrement. In order to evaluate, the correlation between pattern and severity of PD, we divided 13 patients, who underwent measurement of pedaling patterns more than three times, into three groups, and found that the abnormal coordination pattern correlated with the presence of freezing phenomenon in patients with PD. Our clinical analysis may contribute in analyzing and classifying the dynamics of PD.
Authors:
Kazuo Abe; Yoshiyuki Asai; Yoshimi Matsuo; Taishin Nomura; Shunsuke Sato; Satoru Inoue; Isao Mizukura; Sabro Sakoda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  61     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-30     Completed Date:  2003-09-02     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
Affiliation:
D-4, Department of Neurology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. abe@neurol.med.osaka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biomechanics
Cluster Analysis
Exercise / physiology
Female
Humans
Leg*
Male
Middle Aged
Motor Skills
Movement Disorders / etiology*
Neuropsychological Tests
Parkinson Disease / classification*,  complications
Psychomotor Performance
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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