Document Detail


Classification of unit types in the anteroventral cochlear nucleus of laboratory mice.
MedLine Citation:
PMID:  22579638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report introduces a system for the objective physiological classification of single-unit activity in the anteroventral cochlear nucleus (AVCN) of anesthetized CBA/129 and CBA/CaJ mice. As in previous studies, the decision criteria are based on the temporal properties of responses to short tone bursts that are visualized in the form of peri-stimulus time histograms (PSTHs). Individual unit types are defined by the statistical distribution of quantifiable metrics that relate to the onset latency, regularity, and adaptation of sound-driven discharge rates. Variations of these properties reflect the unique synaptic organizations and intrinsic membrane properties that dictate the selective tuning of sound coding in the AVCN. When these metrics are applied to the mouse AVCN, responses to best frequency (BF) tones reproduce the major PSTH patterns that have been previously demonstrated in other mammalian species. The consistency of response types in two genetically diverse strains of laboratory mice suggests that the present classification system is appropriate for additional strains with normal peripheral function. The general agreement of present findings to established classifications validates laboratory mice as an adequate model for general principles of mammalian sound coding. Nevertheless, important differences are noted for the reliability of specialized endbulb transmission within the AVCN, suggesting less secure temporal coding in this high-frequency species.
Authors:
Matthew J Roos; Bradford J May
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-02
Journal Detail:
Title:  Hearing research     Volume:  289     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-10-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-26     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Cochlear Nucleus / cytology,  physiology*
Decision Trees
Evoked Potentials, Auditory, Brain Stem
Female
Male
Mice
Mice, 129 Strain
Mice, Inbred CBA
Models, Neurological
Neurons / classification,  physiology*
Reaction Time
Species Specificity
Synaptic Transmission
Time Factors
Grant Support
ID/Acronym/Agency:
F31 DC010095/DC/NIDCD NIH HHS; F31 DC010095/DC/NIDCD NIH HHS; P30 DC005211/DC/NIDCD NIH HHS; P30DC005211/DC/NIDCD NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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