Document Detail

Classification of tubulo-papillary renal cortical tumours using estimates of nuclear volume.
MedLine Citation:
PMID:  8329199     Owner:  NLM     Status:  MEDLINE    
The classification of renal cortical tumours is problematic, with no clear division of benign from malignant tumours. Unbiased stereological estimates of volume-weighted nuclear volume (nuclear vv) were obtained by point sampling of nuclear intercepts in a retrospective study of 36 variably sized tubulo-papillary basophilic cell renal cortical tumours. There was no clear pattern of evolution of nuclear vv with increasing macroscopic tumour diameter. Estimates of nuclear vv could not distinguish between 21 tumours classified as renal adenomas with macroscopic diameters < 3 cm (average nuclear vv = 241 microns 3) and 15 tumours classified as renal cell carcinomas with diameters > 3 cm, or aggressive histological pattern (average nuclear vv = 229 microns 3) (2p = 0.68). In this subtype of renal cortical tumours, estimates of nuclear vv do not support the historical convention of using a 3 cm tumour diameter as the dividing line between adenomas and carcinomas, but support the theory of a single group of tumours. As most of the truly incidental renal cortical tumours are less than 1 cm in diameter, this limit could be considered. Such small benign cortical nodules have never been reported to metastasize, and would thus be excluded from being diagnosed and registered as malignant. Although this dividing line is again arbitrary, and cannot be justified by the stereological measurements, it is a practical solution to a clinical problem. There were too few examples of disease progression to assess the prognostic significance of nuclear vv in these tumours.
B Brooks; F B Sørensen; S Olsen; P Holm-Nielsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  101     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  378-86     Citation Subset:  IM    
University Institute of Pathology, Aarhus Kommunehospital, Denmark.
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MeSH Terms
Adenoma / classification,  pathology
Aged, 80 and over
Carcinoma, Renal Cell / classification,  pathology
Cell Nucleus / pathology*
Image Processing, Computer-Assisted
Kidney / pathology*
Kidney Cortex / pathology
Kidney Medulla / pathology
Kidney Neoplasms / classification*,  pathology
Kidney Tubules / pathology
Middle Aged
Retrospective Studies

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