| Classification and properties of acidic amino acid receptors in hippocampus. III. Supersensitivity during the postnatal period and following denervation. | |
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MedLine Citation:
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PMID: 6136903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of excitatory amino acids on 22Na efflux rate in rat hippocampal slices were determined at various postnatal days and following removal of a major afferent system. Two weeks after a unilateral hippocampal aspiration, the 22Na efflux induced by potassium ions, D-glutamate, N-methylaspartate, and kainate is significantly decreased in the contralateral intact hippocampus whereas the effect of L-glutamate is substantially increased. Analysis of concentration-response curves suggests that the increased responsiveness to L-glutamate is due to an increase in the maximal effect rather than to changes in the half-maximal concentration for the amino acid. Partial denervation does not detectably change efflux elicited by D,L-homocysteic acid nor does it modify the properties of [3H]glutamate binding to hippocampal membranes. The effects of potassium ions, N-methylaspartate, and kainate but not of D,L-homocysteate are significantly decreased in slices incubated in the absence of calcium. All of the amino acids tested are considerably more potent in slices prepared from 11-day-old rats than in those from adult rats; the differences in responsiveness reflect an increase in maximal effect without changes in the half-maximal concentration. The responses to L-glutamate and D,L-homocysteate decline steadily between postnatal days 11 and 30, at which time adult values are reached. Together, the results from the denervation and development studies suggest a different localization and different modes of regulation for various classes of excitatory amino acid receptors. |
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Authors:
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M Baudry; K Kramer; G Lynch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Molecular pharmacology Volume: 24 ISSN: 0026-895X ISO Abbreviation: Mol. Pharmacol. Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-10-28 Completed Date: 1983-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0035623 Medline TA: Mol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 229-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Biological Transport / drug effects Denervation Glutamates / pharmacology Glutamic Acid Hippocampus / growth & development, metabolism* Rats Rats, Inbred Strains Receptors, Amino Acid Receptors, Cell Surface / classification* Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Receptors, Amino Acid; 0/Receptors, Cell Surface; 56-86-0/Glutamic Acid; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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