Document Detail


Classification and properties of acidic amino acid receptors in hippocampus. III. Supersensitivity during the postnatal period and following denervation.
MedLine Citation:
PMID:  6136903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of excitatory amino acids on 22Na efflux rate in rat hippocampal slices were determined at various postnatal days and following removal of a major afferent system. Two weeks after a unilateral hippocampal aspiration, the 22Na efflux induced by potassium ions, D-glutamate, N-methylaspartate, and kainate is significantly decreased in the contralateral intact hippocampus whereas the effect of L-glutamate is substantially increased. Analysis of concentration-response curves suggests that the increased responsiveness to L-glutamate is due to an increase in the maximal effect rather than to changes in the half-maximal concentration for the amino acid. Partial denervation does not detectably change efflux elicited by D,L-homocysteic acid nor does it modify the properties of [3H]glutamate binding to hippocampal membranes. The effects of potassium ions, N-methylaspartate, and kainate but not of D,L-homocysteate are significantly decreased in slices incubated in the absence of calcium. All of the amino acids tested are considerably more potent in slices prepared from 11-day-old rats than in those from adult rats; the differences in responsiveness reflect an increase in maximal effect without changes in the half-maximal concentration. The responses to L-glutamate and D,L-homocysteate decline steadily between postnatal days 11 and 30, at which time adult values are reached. Together, the results from the denervation and development studies suggest a different localization and different modes of regulation for various classes of excitatory amino acid receptors.
Authors:
M Baudry; K Kramer; G Lynch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Molecular pharmacology     Volume:  24     ISSN:  0026-895X     ISO Abbreviation:  Mol. Pharmacol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0035623     Medline TA:  Mol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Biological Transport / drug effects
Denervation
Glutamates / pharmacology
Glutamic Acid
Hippocampus / growth & development,  metabolism*
Rats
Rats, Inbred Strains
Receptors, Amino Acid
Receptors, Cell Surface / classification*
Sodium / metabolism
Chemical
Reg. No./Substance:
0/Glutamates; 0/Receptors, Amino Acid; 0/Receptors, Cell Surface; 56-86-0/Glutamic Acid; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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