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Classification of noncalcified coronary atherosclerotic plaque components on CT coronary angiography: impact of vascular attenuation and density thresholds.
MedLine Citation:
PMID:  22095413     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: The authors assessed the effect of vascular attenuation and density thresholds on the classification of noncalcified plaque by computed tomography coronary angiography (CTCA). MATERIALS AND METHODS: Thirty patients (men 25; age 59±8 years) with stable angina underwent arterial and delayed CTCA. At sites of atherosclerotic plaque, attenuation values (HU) were measured within the coronary lumen, noncalcified and calcified plaque material and the surrounding epicardial fat. Based on the measured CT attenuation values, coronary plaques were classified as lipid rich (attenuation value below the threshold) or fibrous (attenuation value above the threshold) using 30-HU, 50-HU and 70-HU density thresholds. RESULTS: One hundred and sixty-seven plaques (117 mixed and 50 noncalcified) were detected and assessed. The attenuation values of mixed plaques were higher than those of exclusively noncalcified plaques in both the arterial (148.3±73.1 HU vs. 106.2±57.9 HU) and delayed (111.4±50.5 HU vs. 64.4±43.4 HU) phases (p<0.01). Using a 50-HU threshold, 12 (7.2%) plaques would be classified as lipid rich on arterial scan compared with 28 (17%) on the delayed-phase scan. Reclassification of these 16 (9.6%) plaques from fibrous to lipid rich involved 4/30 (13%) patients. CONCLUSIONS: Classification of coronary plaques as lipid rich or fibrous based on absolute CT attenuation values is significantly affected by vascular attenuation and density thresholds used for the definition.
Authors:
E Maffei; K Nieman; C Martini; O Catalano; S Seitun; T Arcadi; R Malagò; A Rossi; A Clemente; N R Mollet; F Cademartiri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-17
Journal Detail:
Title:  La Radiologia medica     Volume:  -     ISSN:  1826-6983     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177625     Medline TA:  Radiol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiovascular Imaging, Giovanni XXIII Clinic, Monastier (TV), Italy.
Vernacular Title:
Classificazione delle componenti aterosclerotiche non calcifiche delle placche coronariche mediante angiografia coronarica TC: impatto dell'attenuazione vascolare e delle soglie di densità
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