Document Detail

Classification of human coronary atherosclerotic plaques using ex vivo high-resolution multicontrast-weighted MRI compared with histopathology.
MedLine Citation:
PMID:  22528895     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of our study was to evaluate the feasibility of ex vivo high-resolution multicontrast-weighted MRI to accurately classify human coronary atherosclerotic plaques according to the American Heart Association classification.
MATERIALS AND METHODS: Thirteen human cadaver heart specimens were imaged using high-resolution multicontrast-weighted MR technique (T1-weighted, proton density-weighted, and T2-weighted). All MR images were matched with histopathologic sections according to the landmark of the bifurcation of the left main coronary artery. The sensitivity and specificity of MRI for the classification of plaques were determined, and Cohen's kappa analysis was applied to evaluate the agreement between MRI and histopathology in the classification of atherosclerotic plaques.
RESULTS: One hundred eleven MR cross-sectional images obtained perpendicular to the long axis of the proximal left anterior descending artery were successfully matched with the histopathologic sections. For the classification of plaques, the sensitivity and specificity of MRI were as follows: type I-II (near normal), 60% and 100%; type III (focal lipid pool), 80% and 100%; type IV-V (lipid, necrosis, fibrosis), 96.2% and 88.2%; type VI (hemorrhage), 100% and 99.0%; type VII (calcification), 93% and 100%; and type VIII (fibrosis without lipid core), 100% and 99.1%, respectively. Isointensity, which indicates lipid composition on histopathology, was detected on MRI in 48.8% of calcified plaques. Agreement between MRI and histopathology for plaque classification was 0.86 (p < 0.001).
CONCLUSION: Ex vivo high-resolution multicontrast-weighted MRI can accurately classify advanced atherosclerotic plaques in human coronary arteries.
Tao Li; Xin Li; Xihai Zhao; Weihua Zhou; Zulong Cai; Li Yang; Aitao Guo; Shaohong Zhao
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  198     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-07-19     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1069-75     Citation Subset:  AIM; IM    
Department of Radiology, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
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MeSH Terms
Aged, 80 and over
Contrast Media / diagnostic use
Coronary Artery Disease / pathology*
Dextrans / diagnostic use
Feasibility Studies
Magnetic Resonance Imaging / methods*
Magnetite Nanoparticles / diagnostic use
Middle Aged
Plaque, Atherosclerotic / pathology*
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 0/Magnetite Nanoparticles; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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