Document Detail

Classification and functions of enteroendocrine cells of the lower gastrointestinal tract.
MedLine Citation:
PMID:  21518048     Owner:  NLM     Status:  MEDLINE    
With over thirty different hormones identified as being produced in the gastrointestinal (GI) tract, the gut has been described as 'the largest endocrine organ in the body' (Ann. Oncol., 12, 2003, S63). The classification of these hormones and the cells that produce them, the enteroendocrine cells (EECs), has provided the foundation for digestive physiology. Furthermore, alterations in the composition and function of EEC may influence digestive physiology and thereby associate with GI pathologies. Whilst there is a rapidly increasing body of data on the role and function of EEC in the upper GI tract, there is a less clear-cut understanding of the function of EEC in the lower GI. Nonetheless, their presence and diversity are indicative of a role. This review focuses on the EECs of the lower GI where new evidence also suggests a possible relationship with the development and progression of primary adenocarcinoma.
Ashok R Gunawardene; Bernard M Corfe; Carolyn A Staton
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-04-25
Journal Detail:
Title:  International journal of experimental pathology     Volume:  92     ISSN:  1365-2613     ISO Abbreviation:  Int J Exp Pathol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-04     Completed Date:  2011-09-08     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9014042     Medline TA:  Int J Exp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-31     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. International Journal of Experimental Pathology © 2011 International Journal of Experimental Pathology.
Department of Oncology, The Medical School, University of Sheffield, Sheffield, UK.
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MeSH Terms
Adenocarcinoma / pathology,  physiopathology
Colorectal Neoplasms / pathology,  physiopathology
Digestion / physiology
Disease Progression
Enteroendocrine Cells / classification*,  cytology,  physiology*
Gastrointestinal Diseases / pathology,  physiopathology
Lower Gastrointestinal Tract / cytology*

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