Document Detail

Classification and detection of bone marrow lesions with magnetic resonance imaging.
MedLine Citation:
PMID:  9840389     Owner:  NLM     Status:  MEDLINE    
A logical approach to bone marrow alterations is proposed that takes into account the high sensitivity and specificity of MR imaging for the detection of marrow fat. Marrow signal intensity on T1-weighted images is assumed to reflect the balance between fat and nonfat marrow components. Elementary patterns of marrow change include marrow depletion, infiltration, replacement and signal void. These patterns can be observed alone or in combination, and can be distributed in a focal or diffuse manner. Marrow depletion pattern shows high signal intensity reflecting increase in fat content and is frequently irrelevant clinically. Signal intensity is decreased in marrow infiltration, replacement and signal void patterns, which indicates partial or complete disappearance of fat. Focal marrow infiltration is frequently reactive to an adjacent abnormality, whereas focal marrow replacement more frequently indicates a more profound marrow alteration. The T1-weighted spin-echo sequence is satisfactory for lesion detection by virtue of its relatively high sensitivity in the detection of altered fat/nonfat marrow balance. T2-weighted sequences with saturation of the signal of fat protons or out-of-phase gradient-echo sequences improve lesion conspicuity in all situations in which the difference in fat/nonfat marrow balance between the abnormal area and the adjacent normal marrow is reduced.
B C Vande Berg; J Malghem; F E Lecouvet; B Maldague
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Skeletal radiology     Volume:  27     ISSN:  0364-2348     ISO Abbreviation:  Skeletal Radiol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-20     Completed Date:  1999-01-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7701953     Medline TA:  Skeletal Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  529-45     Citation Subset:  IM    
Department of Radiology and Medical Imaging, University Hospital St. Luc, Brussels, Belgium.
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MeSH Terms
Bone Marrow / pathology*
Bone Marrow Diseases / classification*,  diagnosis*
Diagnosis, Differential
Magnetic Resonance Imaging*
Middle Aged
Sensitivity and Specificity

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