| Classification and characteristics of interferon-related diabetes mellitus in Japan. | |
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MedLine Citation:
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PMID: 21269387 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: The aim of this study was to assess the classification and clinical characteristics of interferon (IFN)-related diabetes. Methods: Cases with IFN-related diabetes in Japan were retrieved through web search engines for medical literature until July in 2009, and unreported data were obtained from the authors by letter or e-mail. Results: We collected 143 cases with IFN-related diabetes consisting of 104 type 1 diabetes including 4 own cases, and 39 non-autoimmune type 2-like diabetes. We found a marked increase in IFN-related type 1 diabetes for these 3 years. In contrast, no increase was observed in IFN-related type 2-like diabetes in the literature. Polyethylene glycol (PEG)-IFN and ribavirin had been more frequently used in patients with type 1 diabetes than in patients with type 2-like diabetes. The age of diabetes onset was comparable between type 1 and type 2-like diabetes, while the ratio of male patients was higher and the latency before diabetes was shorter in type 2-like diabetes. Patients with IFN-related type 1 diabetes had HLA types susceptible to Japanese type 1 diabetic patients, and a high positive rate of GAD antibodies. Conclusion: Potent combination therapy with PEG-IFN and ribavirin is likely associated with the increase in IFN-related type 1 diabetes. The combined measurement of GAD antibody and HLA-typing could be an effective strategy to predict the onset of type 1 diabetes associated with IFN therapy. |
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Authors:
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Kazuhisa Muraishi; Yuko Sasaki; Tomoko Kato; Chizuko Inada; Yuji Tajiri; Kentaro Yamada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: 41 ISSN: 1386-6346 ISO Abbreviation: Hepatol. Res. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 184-8 Citation Subset: - |
Copyright Information:
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© 2011 The Japan Society of Hepatology. |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine Inada Naika Clinic, Kurume, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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