Document Detail

Classification of antiarrhythmic drugs based on ventricular fibrillation threshold.
MedLine Citation:
PMID:  2480703     Owner:  NLM     Status:  MEDLINE    
The antifibrillatory action of antiarrhythmic drugs, classified on the basis of their effects on ventricular fibrillation threshold (VFT), was investigated. The relation between drug action and cardiac excitability, orthodromic/antidromic conduction through Purkinje fibers and ventricular muscle and the restitution of premature action potential duration was studied. Drug classifications were: group A, VFT markedly increased; group B, VFT moderately increased; and group C, no significant change. Group A was subdivided according to presence or absence of the dip phenomenon and supernormal period in the anodal strength-interval curve. Drugs in group A significantly reduced the difference between effective refractory period of orthodromic and antidromic conduction and the range over which the premature action potential duration reappeared. In groups B and C, the effective refractory period in orthodromic conduction was longer than that in controls, and the range of the restitution of premature action potential duration for Purkinje fibers was reduced only slightly.
K Harumi; T Tsutsumi; T Sato; S Sekiya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  64     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-17     Completed Date:  1990-01-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  10J-14J     Citation Subset:  AIM; IM    
Division of Cardiology, Showa University Fujigaoka Hospital, Japan.
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MeSH Terms
Action Potentials
Anti-Arrhythmia Agents / classification*,  therapeutic use
Cardiac Complexes, Premature / physiopathology
Differential Threshold
Heart / drug effects
Heart Conduction System / physiopathology
Papillary Muscles / physiopathology
Purkinje Fibers / physiopathology
Reaction Time
Ventricular Fibrillation / prevention & control*
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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