Document Detail

Classical neurotransmitters and neuropeptides involved in major depression: a review.
MedLine Citation:
PMID:  20583898     Owner:  NLM     Status:  In-Process    
We propose several pathways that could be involved in major depression. According to our proposal, noradrenaline hypoactivity could occur through a strong presynaptic GABAergic inhibition, via GABA(B) receptors, and serotonin hypoactivity through a strong glutaminergic inhibition via subreceptor 5 of the metabotropic glutaminergic receptor. In this sense, it is important to know whether the antagonists of such receptors might be able to improve the symptoms observed in major depression. Some neuropeptides are also altered in such states (corticotropin-releasing hormone, neuropeptide Y, galanin). It is also important to know whether in addition to current antidepressants the administration of neuropeptides and their agonists/antagonists could ameliorate depressive symptoms.
Felix-Martin Werner; Rafael Coveñas
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  120     ISSN:  1563-5279     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  455-70     Citation Subset:  IM    
Höhere Berufsfachschule für Altenpflege und Ergotherapie der Euro-Schulen Pössneck, Pössneck, Germany.
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