| Classical forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency in adults. | |
| | |
MedLine Citation:
|
PMID: 18204267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During childhood, the main aims of the medical treatment of congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase are to prevent salt loss and virilization and to attain normal stature and normal puberty. As such, there is a narrow therapeutic window through which the intended results can be achieved. In adulthood, the clinical management has received little attention, but recent studies have shown the relevance of long-term follow-up of these patients. The aims here are to review the multiple clinical, hormonal and metabolic abnormalities that could be found in adult CAH patients as such a decrease in bone mineral density, overweight and disturbed reproductive functions. In women with classic CAH, a low fertility rate is reported, and is probably the consequence of multiple factors including neuroendocrine and hormonal factors, feminizing surgery, and psychological factors. Men with CAH may present hypogonadism either through the effect of adrenal rests or from suppression of gonadotropins resulting in infertility. Therefore a multidisciplinary team with knowledge of CAH should carefully follow up these patients, from childhood through to adulthood, to avoid these complications and to ensure treatment compliance and tight control of the adrenal androgens. |
| | |
Authors:
|
Anne Bachelot; Zeina Chakthoura; Agnès Rouxel; Jérome Dulon; Philippe Touraine |
Related Documents
:
|
3400697 - Pituitary gland growth during normal pregnancy: an in vivo study using magnetic resonan... 9679507 - Analyzing amenorrhea. 18209867 - Cushing's syndrome in pregnancy: an overview. 11041447 - Endocrine and paracrine regulation of birth at term and preterm. 3051877 - Normal placental function and fetoplacental blood circulation in advanced abdominal pre... 12820837 - Influence of pre-eclampsia on fetal growth. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-01-21 |
Journal Detail:
|
Title: Hormone research Volume: 69 ISSN: 1423-0046 ISO Abbreviation: Horm. Res. Publication Date: 2008 |
Date Detail:
|
Created Date: 2008-04-17 Completed Date: 2008-05-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0366126 Medline TA: Horm Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 203-11 Citation Subset: IM |
Copyright Information:
|
(c) 2008 S. Karger AG, Basel |
Affiliation:
|
Department of Endocrinology and Reproductive Medicine, Groupe Hospitalier Pitié-Salpétrière, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Hyperplasia, Congenital
/
complications,
etiology*,
therapy Adult Humans Infertility / etiology Metabolism, Inborn Errors / complications* Obesity / etiology Osteoporosis / etiology Steroid 21-Hydroxylase / metabolism* |
| Chemical | |
Reg. No./Substance:
|
EC 1.14.99.10/Steroid 21-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up.
Next Document: Metabolic control and growth during exclusive growth hormone treatment in X-linked hypophosphatemic ...