Document Detail

Classical conditioning in the rat fetus: involvement of mu and kappa opioid systems in the conditioned response.
MedLine Citation:
PMID:  11857325     Owner:  NLM     Status:  MEDLINE    
When the Embryonic Day 20 (E20) rat fetus is given a conditioning trial involving a paired presentation of an artificial nipple (the conditioned stimulus; CS) with an intraoral infusion of milk (the unconditioned stimulus; US), it shows evidence of classical conditioning when again exposed to the CS during a test trial. Specifically, the fetus shows fewer oral grasp responses (the conditioned response; CR) when continuously presented with the artificial nipple. The present study further investigated this classically conditioned reduction in oral grasping. Separate experiments (a) examined the time course of the reduction in oral grasping (Experiment 1), (b) characterized the time course of mu opioid (Experiment 2) and kappa opioid (Experiment 3) involvement in the CR, and (c) described changes in fetal behavior (Experiment 4) associated with mu and kappa opioid effects on responding to the artificial nipple. The results are discussed in terms of opioid involvement in establishing and maintaining early suckling behavior.
William P Smotherman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental psychobiology     Volume:  40     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-21     Completed Date:  2002-05-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  104-15     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley Periodicals, Inc.
Department of Psychology, University of Massachusetts, Amherst, MA 01003-7710, USA.
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MeSH Terms
Association Learning / physiology
Conditioning, Classical / physiology*
Fetus / physiology*
Gestational Age
Mental Recall / physiology
Rats, Sprague-Dawley
Receptors, Opioid, kappa / physiology*
Receptors, Opioid, mu / physiology*
Sucking Behavior / physiology*
Grant Support
Reg. No./Substance:
0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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