Document Detail

Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleen.
MedLine Citation:
PMID:  18486899     Owner:  NLM     Status:  MEDLINE    
Combination of the splenic marginal zone B-cell lymphoma (SMZL) and classical Hodgkin lymphoma (cHL) is extremely rare. We report a unique case with concurrent SMZL and cHL. The patient was a 63-year-old man who presented with fatigue and anemia, showing a splenomegaly and retroperitoneal lymphadenopathy. A splenectomy revealed monotonous marginal zone lymphocytic infiltrates and numerous large Reed-Sternberg-like cells. Flow cytometry revealed a kappa light-chain-restricted CD5 (-), CD23 (-) B-cell population. DNA polymerase chain reaction analysis confirmed the presence of clonal rearrangement of the immunoglobulin heavy-chain gene. Immunohistochemical studies revealed that the large atypical cells were CD30 (+), CD15 (weakly +), CD20 (-), CD45 (-), Pax5 (weakly +), BOB.1 (-), and Oct2 (-), indicating the coexistence of SMZL with cHL. After the chemotherapy, the patient achieved a clinical/radiologic remission, whereas cHL was detected in liver and bone marrow subsequently. The case indicates that both components of lymphoma can present concurrently as a composite form of lymphoma and both need to be treated adequately.
Shuko Harada; Hari Kalla; Manjula Balasubramanian; Isadore Brodsky; Douglas Gladstone; J Steve Hou
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-09-14
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  12     ISSN:  1532-8198     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-6     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
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MeSH Terms
Antigens, CD / analysis
B-Lymphocytes / chemistry,  pathology
Combined Modality Therapy
Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
Hodgkin Disease / genetics,  pathology*,  therapy
Lymphatic Diseases
Lymphoma, B-Cell, Marginal Zone / genetics,  pathology*,  therapy
Middle Aged
Neoplasms, Second Primary / pathology*
Reed-Sternberg Cells / pathology
Remission Induction
Splenic Neoplasms / genetics,  pathology*,  therapy
Reg. No./Substance:
0/Antigens, CD

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