Document Detail

Classic papers symposium: history of medicine series: surrogate indexes of target organ involvement in hypertension.
MedLine Citation:
PMID:  8900386     Owner:  NLM     Status:  MEDLINE    
This review of previous work provides credence that the fourth heart sound associated with electrocardiographic evidence of left atrial abnormality and hyperuricemia is an easily determined and cost-effective clinically determined functional surrogates of hypertensive heart and kidney involvement, respectively. These routinely obtained clinically measurable indexes are well established and are pathophysiologically related to the functional involvement of the heart and kidney from hypertensive cardiovascular disease. Moreover, these seemingly nonspecific findings provide strong clinical support for feasible means to determine the independent risk of hypertensive left ventricular hypertrophy and renal involvement in patients with hypertension. In these times of using routine clinical information for cost-effective outcomes, those measurements provide excellent surrogate pathophysiologic indices.
E D Frohlich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  312     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1996-12-06     Completed Date:  1996-12-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  AIM; IM    
Alton Oschner Medical Foundation, New Orleans, Louisiana, USA.
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MeSH Terms
Heart Diseases / etiology*
Hypertension / complications*
Hypertrophy, Left Ventricular / etiology
Kidney Diseases / etiology*

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