Document Detail

Classic and molecular cytogenetic analyses reveal chromosomal gains and losses correlated with survival in head and neck cancer patients.
MedLine Citation:
PMID:  15701849     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patients with similar clinical and histopathologic characteristics but having differential probabilities of survival. The purpose of this study was to investigate chromosomal alterations in head and neck carcinomas and to correlate the results with clinical and epidemiologic variables. EXPERIMENTAL DESIGN: Cytogenetic analysis of short-term cultures from 64 primary untreated head and neck squamous cell carcinomas was used to determine the overall pattern of chromosome aberrations. A representative subset of tumors was analyzed in detail by spectral karyotyping and/or confirmatory fluorescence in situ hybridization analysis. RESULTS: Recurrent losses of chromosomes Y (26 cases) and 19 (14 cases), and gains of chromosomes 22 (23 cases), 8 and 20 (11 cases each) were observed. The most frequent structural aberration was del(22)(q13.1) followed by rearrangements involving 6q and 12p. The presence of specific cytogenetic aberrations was found to correlate significantly with an unfavorable outcome. There was a significant association between survival and gains in chromosomes 10 (P = 0.008) and 20 (P = 0.002) and losses of chromosomes 15 (P = 0.005) and 22 (P = 0.021). Univariate analysis indicated that acquisition of monosomy 17 was a significant (P = 0.0012) factor for patients with a previous family history of cancer. CONCLUSIONS: The significant associations found in this study emphasize that alterations of distinct regions of the genome may be genetic biomarkers for a poor prognosis. Losses of chromosomes 17 and 22 can be associated with a family history of cancer.
N?dia Aparecida B?rgamo; Luciana Caricati da Silva Veiga; Patricia Pintor dos Reis; In?s Nobuko Nishimoto; Jos? Magrin; Luiz Paulo Kowalski; Jeremy A Squire; S?lvia Regina Rogatto
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  11     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-09     Completed Date:  2005-05-12     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  621-31     Citation Subset:  IM    
Department of Genetics, Institute of Biosciences and NeoGene Laboratory, Department of Urology, Faculty of Medicine, S?o Paulo State University, CEP 18618-999, Rua Botucatu, S?o Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / genetics*,  mortality
Chromosome Aberrations*
Chromosome Mapping
DNA, Neoplasm / genetics
Head and Neck Neoplasms / genetics*,  mortality
In Situ Hybridization, Fluorescence
Middle Aged
Neoplasm Staging
Spectral Karyotyping*
Survival Rate
Reg. No./Substance:
0/DNA, Neoplasm

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