| Class II antigens on canine T lymphocytes. | |
| | |
MedLine Citation:
|
PMID: 2411015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A panel of crossreactive anti-human, -mouse and -rat MHC class II monoclonal antibodies (Mabs) was used to examine MHC class II antigen expression on canine T lymphocytes by cytofluorometry. The presence of MHC class II antigens was demonstrated on activated T lymphoblasts as well as on non-stimulated peripheral blood T lymphocytes. A number of anti-MHC class II Mabs reacted only with activated T lymphoblasts. Immunoprecipitation studies confirmed the Ia-like or MHC class II molecular character of the antigens on canine T cells. The expression of MHC class II antigens on peripheral blood T lymphocytes appeared to be not induced by stimulation of the T cells, as purified T lymphocytes of specific pathogen free dogs reacted with anti-MHC class II Mabs. Moreover, the study indicates that MHC class II antigen expression is present in the neonatal thymus. Lectin stimulated and allogeneically stimulated T lymphoblasts showed a stronger expression of MHC class II antigens in comparison with non-stimulated T cells. |
| | |
Authors:
|
R F Doveren; W A Buurman; B Schutte; G Groenewegen; C J van der Linden |
Related Documents
:
|
8179965 - Simian immunodeficiency virus sivsmmpbj 1.9 induces multinucleated giant cell formation... 3135295 - Rat ependyma and microglia cells express class ii mhc antigens after intravenous infusi... 1905425 - Biochemical analysis of class i and class ii mhc antigens in cynomolgus macaques by one... 11441095 - Regulation of mhc class ii antigen presentation by sorting of recycling hla-dm/do and c... 21096355 - Model-based optimal immunization for antibody production in birds. 8533285 - The effects of continuous and intermittent delivery of antigens of boophilus microplus ... |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Tissue antigens Volume: 25 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 1985 May |
Date Detail:
|
Created Date: 1985-09-24 Completed Date: 1985-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 255-65 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Antibodies, Monoclonal / immunology Dogs / immunology* Epitopes / immunology Histocompatibility Antigens / immunology* Humans Lymphocyte Activation Mice Phytohemagglutinins / pharmacology Specific Pathogen-Free Organisms T-Lymphocytes / immunology* T-Lymphocytes, Cytotoxic / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Epitopes; 0/Histocompatibility Antigens; 0/Phytohemagglutinins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surgical implications of early branching of the left coronary artery in anatomic correction of trans...
Next Document: Actions of Ptychodiscus brevis toxins on nerve and muscle membranes.