Document Detail

Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL.
MedLine Citation:
PMID:  15251115     Owner:  NLM     Status:  MEDLINE    
To evaluate the anti-inflammatory action of macrolide antibiotics, we examined whether macrolide antibiotics could induce apoptosis of activated lymphocytes. The proportion of apoptotic cells was augmented by clarithromycin (CLR) and azithromycin (AZM) compared with control. There was no significant difference in Fas and Fas-ligand expression between the control and macrolide-treated groups. CLR and AZM inhibited the expression of Bcl-xL compared with that of control. Our results suggest that CLR and AZM enhance apoptosis of activated lymphocytes by down-regulation of Bcl-xL.
Syunji Mizunoe; Jun-Ichi Kadota; Issei Tokimatsu; Kenji Kishi; Hiroyuki Nagai; Masaru Nasu
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International immunopharmacology     Volume:  4     ISSN:  1567-5769     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-07-14     Completed Date:  2005-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1201-7     Citation Subset:  IM    
Division of Pathogenesis and Disease Control, Department of Infectious Diseases, Oita University Faculty of Medicine, 1-1 Hasama, Oita 879-5593, Japan.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Antigen-Presenting Cells
Antigens, CD28 / immunology
Antigens, CD3 / immunology
Antigens, CD95 / biosynthesis
Apoptosis / drug effects*
Azithromycin / pharmacology*
Cells, Cultured
Clarithromycin / pharmacology*
Down-Regulation / drug effects,  physiology
Fas Ligand Protein
Lymphocyte Activation / drug effects
Lymphocytes / drug effects*,  immunology
Membrane Glycoproteins / biosynthesis
Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
Stimulation, Chemical
bcl-2-Associated X Protein
bcl-X Protein
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antigens, CD28; 0/Antigens, CD3; 0/Antigens, CD95; 0/BCL2L1 protein, human; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 0/bcl-X Protein; 81103-11-9/Clarithromycin; 83905-01-5/Azithromycin

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