Document Detail

Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL.
MedLine Citation:
PMID:  15251115     Owner:  NLM     Status:  MEDLINE    
To evaluate the anti-inflammatory action of macrolide antibiotics, we examined whether macrolide antibiotics could induce apoptosis of activated lymphocytes. The proportion of apoptotic cells was augmented by clarithromycin (CLR) and azithromycin (AZM) compared with control. There was no significant difference in Fas and Fas-ligand expression between the control and macrolide-treated groups. CLR and AZM inhibited the expression of Bcl-xL compared with that of control. Our results suggest that CLR and AZM enhance apoptosis of activated lymphocytes by down-regulation of Bcl-xL.
Syunji Mizunoe; Jun-Ichi Kadota; Issei Tokimatsu; Kenji Kishi; Hiroyuki Nagai; Masaru Nasu
Related Documents :
8562965 - Fanconi anemia genes act to suppress a cross-linker-inducible p53-independent apoptosis...
9256475 - Precursor b cells for autoantibody production in genomically fas-intact autoimmune dise...
11220355 - Dissociation between fas expression and induction of apoptosis in human islets of lange...
10611305 - Activation of fas by fasl induces apoptosis by a mechanism that cannot be blocked by bc...
23578665 - Lipopolysaccharide blocks induction of unfolded protein response in human hepatoma cell...
18634875 - Uncovering mechanisms of bistability in biological systems.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International immunopharmacology     Volume:  4     ISSN:  1567-5769     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-07-14     Completed Date:  2005-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1201-7     Citation Subset:  IM    
Division of Pathogenesis and Disease Control, Department of Infectious Diseases, Oita University Faculty of Medicine, 1-1 Hasama, Oita 879-5593, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents / pharmacology*
Antigen-Presenting Cells
Antigens, CD28 / immunology
Antigens, CD3 / immunology
Antigens, CD95 / biosynthesis
Apoptosis / drug effects*
Azithromycin / pharmacology*
Cells, Cultured
Clarithromycin / pharmacology*
Down-Regulation / drug effects,  physiology
Fas Ligand Protein
Lymphocyte Activation / drug effects
Lymphocytes / drug effects*,  immunology
Membrane Glycoproteins / biosynthesis
Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
Stimulation, Chemical
bcl-2-Associated X Protein
bcl-X Protein
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antigens, CD28; 0/Antigens, CD3; 0/Antigens, CD95; 0/BCL2L1 protein, human; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 0/bcl-X Protein; 81103-11-9/Clarithromycin; 83905-01-5/Azithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lactoferrin works as a new LPS-binding protein in inflammatory activation of macrophages.
Next Document:  Pharmacokinetics of fungal (1-3)-beta-D-glucans following intravenous administration in rats.