Document Detail

Clarithromycin Treatment in Preterm Infants: A Pilot Study for Prevention of Feeding Intolerance.
MedLine Citation:
PMID:  23570248     Owner:  NLM     Status:  Publisher    
Abstract Objective: To compare the effectiveness of oral clarithromycin versus placebo treatment in preventing feeding intolerance in very low birth weight infants. Study Design: A prospective, randomized, controlled trial in which two groups of preterm infants (birth weight < 1500g) were randomized to clarithromycin (7.5 mg/kg/ dose every 12 h) or placebo treatment. During the period 38 infants whose parents accepted participation were enrolled in the study. Feeding intolerance and time to achieve full enteral feeding were considered as primary outcome measures. Results: Feeding intolerance was significantly longer in the placebo than clarithromycin (p= 0.031). Time to achieve full feeding after begining the treatment was equal among the groups. Conclusion: This is the first randomised controlled study of clarithromycin and placebo treatment that compares the improvement of feeding intolerance in very low birth weight infants. Our findings indicate a dramatic improvement in feeding intolerance after oral clarithromycin treatment. But according to our results clarithromycin treated infants were not able to attain full enteral feeding more quickly than placebo. This may be due to prophylactic usage of clarithromycin. Significant differences might have resulted if only infants who had feeding intolerance were recruited.
Tulin Gokmen; Ramazan Ozdemir; Senol Bozdag; Serife Suna Oguz; Omer Erdeve; Nurdan Uras; Ugur Dilmen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-10
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, TURKEY.
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