Document Detail

Clara cell protein 16 concentration in mid-trimester amniotic fluid: association with fetal gender, fetal G>A +38 CC16 gene polymorphism and pregnancy outcome.
MedLine Citation:
PMID:  16236364     Owner:  NLM     Status:  MEDLINE    
Clara cell protein 16 (CC16) is a major immunomodulatory protein produced in the fetal lung. We hypothesized that the mid-trimester amniotic fluid concentration of CC16 would vary according to a +38 CC16 polymorphism in the fetal genome and that increased levels would be an early indicator of subsequent adverse pregnancy outcome. Mid-trimester singleton amniotic fluids from 244 women were assayed for CC16 by ELISA. DNA from fetal cells in 179 amniotic fluids were tested for the A>G polymorphism at position +38 in exon 1 by PCR. Outcome data were obtained from 233 women after completion of laboratory testing. Median CC16 levels were higher in amniotic fluids containing male fetuses than in those with females (p=0.0005). Median amniotic fluid CC16 levels were higher in Hispanics than in Whites and Asians (p<0.05). CC16*G homozygosity was associated with elevated amniotic fluid CC16 concentrations compared to CC16*A homozygotes (p=0.02). Intraamniotic CC16 levels were highest in pregnancies that subsequently resulted in preterm premature rupture of membranes (PPROM) (p=0.01). We conclude that mid-trimester intraamniotic CC16 concentrations vary by gender, ethnicity and fetal CC16 gene polymorphism. Elevated CC16 levels are predictive of subsequent development of PPROM.
Sriram C Perni; Santosh Vardhana; Robin Kalish; Stephen Chasen; Steven S Witkin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-10-19
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  68     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-03-14     Revised Date:  2009-09-17    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35, NY 10021, USA.
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MeSH Terms
Amniotic Fluid / metabolism*
Biological Markers / analysis
Case-Control Studies
Fetal Membranes, Premature Rupture / genetics*,  metabolism*
Polymorphism, Single Nucleotide*
Predictive Value of Tests
Pregnancy Outcome
Pregnancy Trimester, Second / genetics,  metabolism*
Uteroglobin / analysis*,  genetics*
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Clara cell secretory protein; 9060-09-7/Uteroglobin

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