| Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling). | |
| | |
MedLine Citation:
|
PMID: 18683491 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experiments on Wistar rats showed a decrease in basal and muscimol-stimulated 36Cl(-) entry into synaptoneurosomes isolated from the cerebral cortex during the middle stage of kindling (30 mg/kg pentylenetetrazole intraperitoneally for 14 days) characterized by the development of convulsions of higher (2 points) severity in comparison with the previous stage. |
| | |
Authors:
|
I G Rebrov; M N Karpova; A A Andreev; N Yu Klishina; M V Kalinina; L V Kusnetzova |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Bulletin of experimental biology and medicine Volume: 144 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2008-08-07 Completed Date: 2008-12-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
|
Languages: eng Pagination: 667-9 Citation Subset: IM |
Affiliation:
|
Laboratory of Epileptogenesis, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cerebral Cortex / drug effects, metabolism*, pathology Chlorides / metabolism* Chronic Disease Dose-Response Relationship, Drug Epilepsy / chemically induced, metabolism*, pathology GABA Agonists / administration & dosage, pharmacology GABA Antagonists / administration & dosage, pharmacology Kindling, Neurologic / drug effects, metabolism* Male Muscimol / administration & dosage, pharmacology Pentylenetetrazole / administration & dosage, pharmacology Rats Rats, Wistar Receptors, GABA-A / agonists, antagonists & inhibitors, metabolism* Seizures / chemically induced, metabolism, pathology Synaptic Membranes / drug effects, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Chlorides; 0/GABA Agonists; 0/GABA Antagonists; 0/Receptors, GABA-A; 2763-96-4/Muscimol; 54-95-5/Pentylenetetrazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary...
Next Document: Energy metabolism in rat brain structures after injections of kainic acid into the frontal cortex.