Document Detail

Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
MedLine Citation:
PMID:  18683491     Owner:  NLM     Status:  MEDLINE    
Experiments on Wistar rats showed a decrease in basal and muscimol-stimulated 36Cl(-) entry into synaptoneurosomes isolated from the cerebral cortex during the middle stage of kindling (30 mg/kg pentylenetetrazole intraperitoneally for 14 days) characterized by the development of convulsions of higher (2 points) severity in comparison with the previous stage.
I G Rebrov; M N Karpova; A A Andreev; N Yu Klishina; M V Kalinina; L V Kusnetzova
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  144     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  667-9     Citation Subset:  IM    
Laboratory of Epileptogenesis, Institute of Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
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MeSH Terms
Cerebral Cortex / drug effects,  metabolism*,  pathology
Chlorides / metabolism*
Chronic Disease
Dose-Response Relationship, Drug
Epilepsy / chemically induced,  metabolism*,  pathology
GABA Agonists / administration & dosage,  pharmacology
GABA Antagonists / administration & dosage,  pharmacology
Kindling, Neurologic / drug effects,  metabolism*
Muscimol / administration & dosage,  pharmacology
Pentylenetetrazole / administration & dosage,  pharmacology
Rats, Wistar
Receptors, GABA-A / agonists,  antagonists & inhibitors,  metabolism*
Seizures / chemically induced,  metabolism,  pathology
Synaptic Membranes / drug effects,  metabolism*
Reg. No./Substance:
0/Chlorides; 0/GABA Agonists; 0/GABA Antagonists; 0/Receptors, GABA-A; 2763-96-4/Muscimol; 54-95-5/Pentylenetetrazole

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