Document Detail

Citrulline and albumin as biomarkers for gastrointestinal mucositis in recipients of hematopoietic SCT.
MedLine Citation:
PMID:  23334276     Owner:  NLM     Status:  MEDLINE    
Gastrointestinal (GI) mucositis is a common side effect of intense chemotherapy to prepare patients for hematopoietic SCT. Measuring intestinal damage objectively remains difficult, and clinicians often rely on albumin levels as an indicator of GI mucositis, but citrulline might be a more specific marker, which has in the past been shown to correlate with clinical signs of GI mucositis. We evaluated the courses of albumin and citrulline following different conditioning regimens for SCT and studied their relatedness to the subsequent inflammatory response using C-reactive protein. Patterns of albumin and citrulline differed significantly between myeloablative and non-myeloablative conditioning regimens. After myeloablative regimens, decreasing citrulline levels preceded the occurrence of inflammation unlike albumin levels, which decreased thereafter. Albumin levels were greatly influenced by inflammation, confirming it to be a 'negative acute-phase protein', whereas citrulline levels were not. Citrulline appeared to be a better biomarker of GI mucositis than albumin. Measuring citrulline might prove useful in clinical decision making, in identifying GI mucositis, and it would also be of interest to see how it compares with other biomarkers in the setting of acute GI GVHD.
W J F M van der Velden; A H E Herbers; R J M Brüggemann; T Feuth; J Peter Donnelly; N M A Blijlevens
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study     Date:  2013-01-21
Journal Detail:
Title:  Bone marrow transplantation     Volume:  48     ISSN:  1476-5365     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-07-03     Completed Date:  2014-02-04     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  977-81     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Citrulline / blood*
Graft vs Host Disease / blood*,  etiology
Hematologic Neoplasms / blood,  therapy
Hematopoietic Stem Cell Transplantation*
Middle Aged
Mucositis / blood*,  etiology
Retrospective Studies
Serum Albumin / metabolism*
Transplantation Conditioning*
Grant Support
090532//Wellcome Trust
Reg. No./Substance:
0/Biological Markers; 0/Serum Albumin; 29VT07BGDA/Citrulline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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