Document Detail


Citraturic response to oral citric acid load.
MedLine Citation:
PMID:  1552616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is possible that some orally administered citrate may appear in urine by escaping oxidation in vivo. To determine whether this mechanism contributes to the citraturic response to potassium citrate, we measured serum and urinary citrate for 4 hours after a single oral load of citric acid (40 mEq.) in 6 normal subjects. Since citric acid does not alter acid-base balance, the effect of absorbed citrate could be isolated from that of alkali load. Serum citrate concentration increased significantly (p less than 0.05) 30 minutes after a single oral dose of citric acid and remained significantly elevated for 3 hours after citric acid load. Commensurate with this change, urinary citrate excretion peaked at 2 hours and gradually decreased during the next 2 hours after citric acid load. In contrast, serum and urinary citrate remained unaltered following the control load (no drug). Differences of the citratemic and citraturic effects between phases were significant (p less than 0.05) at 2 and 3 hours. Urinary pH, carbon dioxide pressure, bicarbonate, total carbon dioxide and ammonium did not change at any time after citric acid load, and did not differ between the 2 phases. No significant difference was noted in serum electrolytes, arterialized venous pH and carbon dioxide pressure at any time after citric acid load and between the 2 phases. Thus, the citraturic and citratemic effects of oral citric acid are largely accountable by provision of absorbed citrate, which has escaped in vivo degradation.
Authors:
K Sakhaee; R Alpern; J Poindexter; C Y Pak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  147     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-29     Completed Date:  1992-04-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  975-6     Citation Subset:  AIM; IM; S    
Affiliation:
Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75235-8885.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Citrates / administration & dosage*,  metabolism,  urine*
Citric Acid
Female
Humans
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
M01-RR00633/RR/NCRR NIH HHS; P01-DK20543/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Citrates; 77-92-9/Citric Acid
Investigator
Investigator/Affiliation:
C Y Pak / U TX SW Med Ctr, Dallas

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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