| Citral, an inhibitor of retinoic acid synthesis, modifies chick limb development. | |
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MedLine Citation:
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PMID: 8626029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exogenously applied retinoic acid (RA) is known to affect cartilage pattern in developing and regenerating limbs. There are, however, few reports which analyze the participation of endogenous RA in limb pattern formation. Using an organ culture system, we attempted to reduce the concentration of endogenous RA in the developing chick wing buds by the treatment with citral (3,7-dimethyl-2,6-octadienal), an inhibitor of retinoic acid formation. After this treatment, the cultured wing buds were grafted to the stumps of host embryos. These citral-treated limb buds frequently formed truncated cartilage elements and the defects were rescued by simultaneous treatment with an appropriate concentration of RA. These results suggest that endogenous RA plays a role in chick limb bud development. |
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Authors:
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M Tanaka; K Tamura; H Ide |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental biology Volume: 175 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-06-26 Completed Date: 1996-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 239-47 Citation Subset: IM |
Affiliation:
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Biological Institute, Tohoku University, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cartilage / drug effects, embryology Cells, Cultured Chick Embryo Chromatography, High Pressure Liquid Humerus / embryology Mesoderm / cytology Monoterpenes* Morphogenesis / drug effects Organ Culture Techniques Radius / embryology Terpenes / pharmacology* Tretinoin / metabolism*, pharmacology Ulna / embryology Vitamin A / metabolism Wing / drug effects, embryology*, transplantation |
| Chemical | |
Reg. No./Substance:
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0/Monoterpenes; 0/Terpenes; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 5392-40-5/citral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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