Document Detail

Citral, an inhibitor of retinoic acid synthesis, modifies chick limb development.
MedLine Citation:
PMID:  8626029     Owner:  NLM     Status:  MEDLINE    
Exogenously applied retinoic acid (RA) is known to affect cartilage pattern in developing and regenerating limbs. There are, however, few reports which analyze the participation of endogenous RA in limb pattern formation. Using an organ culture system, we attempted to reduce the concentration of endogenous RA in the developing chick wing buds by the treatment with citral (3,7-dimethyl-2,6-octadienal), an inhibitor of retinoic acid formation. After this treatment, the cultured wing buds were grafted to the stumps of host embryos. These citral-treated limb buds frequently formed truncated cartilage elements and the defects were rescued by simultaneous treatment with an appropriate concentration of RA. These results suggest that endogenous RA plays a role in chick limb bud development.
M Tanaka; K Tamura; H Ide
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  175     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-06-26     Completed Date:  1996-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
Biological Institute, Tohoku University, Sendai, Japan.
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MeSH Terms
Cartilage / drug effects,  embryology
Cells, Cultured
Chick Embryo
Chromatography, High Pressure Liquid
Humerus / embryology
Mesoderm / cytology
Morphogenesis / drug effects
Organ Culture Techniques
Radius / embryology
Terpenes / pharmacology*
Tretinoin / metabolism*,  pharmacology
Ulna / embryology
Vitamin A / metabolism
Wing / drug effects,  embryology*,  transplantation
Reg. No./Substance:
0/Monoterpenes; 0/Terpenes; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 5392-40-5/citral

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