Document Detail


Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods.
MedLine Citation:
PMID:  19260039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Cytidine-5'-diphosphocholine (citicoline) has a variety of cognitive enhancing, neuroprotective, and neuroregenerative properties. In cocaine-addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain responses to food are unknown.
METHOD: We compared the effects of treatment with Cognizin citicoline (500 mg/day versus 2,000 mg/day) for 6 weeks on changes in appetite ratings, weight, and cortico-limbic responses to images of high-calorie foods using functional magnetic resonance imaging (fMRI).
RESULTS: After 6 weeks, there was no significant change in weight status, although significant declines in appetite ratings were observed for the 2,000 mg/day group. The higher dose group also showed significant increases in functional brain responses to food stimuli within the amygdala, insula, and lateral orbitofrontal cortex. Increased activation in these regions correlated with declines in appetite ratings.
DISCUSSION: These preliminary findings suggest a potential usefulness of citicoline in modulating appetite, but further research is warranted.
Authors:
William D S Killgore; Amy J Ross; Toshikazu Kamiya; Yoko Kawada; Perry F Renshaw; Deborah A Yurgelun-Todd
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of eating disorders     Volume:  43     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-15     Completed Date:  2010-03-15     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-13     Citation Subset:  IM    
Affiliation:
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA. killgore@mclean.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Appetite / drug effects*
Body Weight / drug effects*
Brain Mapping
Cerebral Cortex / drug effects*,  physiology
Cytidine Diphosphate Choline / pharmacology*
Dose-Response Relationship, Drug
Female
Food
Food Preferences / physiology
Humans
Image Processing, Computer-Assisted
Limbic System / drug effects*,  physiology
Magnetic Resonance Imaging
Male
Middle Aged
Neural Pathways / physiology
Photic Stimulation
Questionnaires
Regression Analysis
Grant Support
ID/Acronym/Agency:
1R01 DA020269/DA/NIDA NIH HHS; R01 DA020269-02/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
987-78-0/Cytidine Diphosphate Choline
Comments/Corrections

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