Document Detail


Cisplatin, vinblastine, and mitoguazone in squamous cell carcinoma of the esophagus: a Southwest Oncology Group Study.
MedLine Citation:
PMID:  3690527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty patients with locally extensive or metastatic squamous cell carcinoma of the esophagus were registered onto a phase II trial employing cisplatin, vinblastine, and mitoguazone. Of 36 eligible patients, four (11%) had partial responses. None had received prior chemotherapy or radiation therapy. Toxicity was mild to moderate and consisted mostly of nausea and vomiting. The activity of this regimen at the doses and schedule used was minimal. More aggressive use of therapy should be considered for further trials.
Authors:
R Chapman; T R Fleming; J Van Damme; J Macdonald
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer treatment reports     Volume:  71     ISSN:  0361-5960     ISO Abbreviation:  Cancer Treat Rep     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-02-03     Completed Date:  1988-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7607107     Medline TA:  Cancer Treat Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1185-7     Citation Subset:  IM    
Affiliation:
Henry Ford Hospital, Detroit, MI.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Squamous Cell / drug therapy*
Cisplatin / administration & dosage
Drug Evaluation
Esophageal Neoplasms / drug therapy*
Female
Humans
Male
Middle Aged
Mitoguazone / administration & dosage
Vinblastine / administration & dosage
Grant Support
ID/Acronym/Agency:
CA-04915/CA/NCI NIH HHS; CA-07429/CA/NCI NIH HHS; CA-32102/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin; 459-86-9/Mitoguazone; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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