Document Detail

Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: cytotoxicity, in vitro carcinogenicity, and cellular uptake.
MedLine Citation:
PMID:  17896762     Owner:  NLM     Status:  MEDLINE    
Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin-loaded Au-Au(2)S nanoparticles (NPs) with near-IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au-Au(2)S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl(4)) using sodium sulfide (Na(2)S), and cisplatin was loaded onto Au-Au(2)S NPs via a MUA (11-mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin-loaded Au-Au(2)S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long-term potential carcinogenicity in vitro. Cisplatin-loaded Au-Au(2)S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long-term data provided preliminary evidence suggesting that cisplatin-loaded Au-Au(2)S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage.
Lei Ren; Xiao-Li Huang; Bin Zhang; Li-Ping Sun; Qi-Qing Zhang; Mei-Chee Tan; Gan-Moog Chow
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  85     ISSN:  1552-4965     ISO Abbreviation:  -     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  787-96     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley Periodicals, Inc.
Research Center of Biomedical Engineering, Medical College, Xiamen University, Xiamen 361005, People's Republic of China.
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MeSH Terms
Antineoplastic Agents / chemical synthesis,  pharmacology
Carcinogenicity Tests
Cell Line
Cell Survival / drug effects
Cisplatin / administration & dosage*,  chemical synthesis
Infrared Rays
Materials Testing
Metal Nanoparticles / chemistry,  therapeutic use*
Neoplasms / therapy*
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin; 7440-57-5/Gold

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