| Cisplatin-loaded Au-Au2S nanoparticles for potential cancer therapy: cytotoxicity, in vitro carcinogenicity, and cellular uptake. | |
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MedLine Citation:
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PMID: 17896762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin-loaded Au-Au(2)S nanoparticles (NPs) with near-IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au-Au(2)S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl(4)) using sodium sulfide (Na(2)S), and cisplatin was loaded onto Au-Au(2)S NPs via a MUA (11-mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin-loaded Au-Au(2)S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long-term potential carcinogenicity in vitro. Cisplatin-loaded Au-Au(2)S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long-term data provided preliminary evidence suggesting that cisplatin-loaded Au-Au(2)S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. |
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Authors:
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Lei Ren; Xiao-Li Huang; Bin Zhang; Li-Ping Sun; Qi-Qing Zhang; Mei-Chee Tan; Gan-Moog Chow |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 85 ISSN: 1552-4965 ISO Abbreviation: - Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-04-28 Completed Date: 2008-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 787-96 Citation Subset: IM |
Copyright Information:
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Copyright 2007 Wiley Periodicals, Inc. |
Affiliation:
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Research Center of Biomedical Engineering, Medical College, Xiamen University, Xiamen 361005, People's Republic of China. renlei@xmu.edu.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemical synthesis,
pharmacology Carcinogenicity Tests Cell Line Cell Survival / drug effects Cisplatin / administration & dosage*, chemical synthesis Gold Humans Infrared Rays Materials Testing Metal Nanoparticles / chemistry, therapeutic use* Neoplasms / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin; 7440-57-5/Gold |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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