| Cisplatin-induced hypomagnesemia and cardiac dysrhythmia. | |
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MedLine Citation:
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PMID: 16619211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a case of a patient with cisplatin-induced hypomagnesemia who suffered brief asystole during an episode of gastroenteritis. Structural heart disease was excluded. The patient achieved complete clinical recovery after short-term administration of intravenous magnesium supplementation. Cisplatin should be considered a cause of hypomagnesemic-related cardiac dysrhythmia. Magnesium deficit may increase myocardial electrical instability and thus, the risk of life-threatening arrhythmias and sudden death. Long-term serum electrolyte measurement and appropriate replacement of magnesium are recommended. |
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Authors:
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Hamid Bashir; Debbie Crom; Monika Metzger; Jean Mulcahey; Debbie Jones; Melissa M Hudson |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 49 ISSN: 1545-5009 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-09-19 Completed Date: 2007-11-13 Revised Date: 2009-01-12 |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 867-9 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / administration & dosage, adverse effects Bleomycin / administration & dosage, adverse effects Bone Neoplasms / complications, therapy Cisplatin / administration & dosage, adverse effects* Cyclophosphamide / administration & dosage, adverse effects Dactinomycin / administration & dosage, adverse effects Doxorubicin / administration & dosage, adverse effects Female Gastroenteritis / drug therapy, etiology Heart Arrest / chemically induced*, drug therapy Humans Magnesium* / administration & dosage Methotrexate / administration & dosage, adverse effects Osteosarcoma / complications, therapy Water-Electrolyte Imbalance / chemically induced*, drug therapy |
| Grant Support | |
ID/Acronym/Agency:
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P30 CA 21765/CA/NCI NIH HHS; R01 CA 85891-05/CA/NCI NIH HHS; R25 CA23944/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11056-06-7/Bleomycin; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 50-76-0/Dactinomycin; 59-05-2/Methotrexate; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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