| Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles. | |
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MedLine Citation:
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PMID: 15979187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To develop a platform for tumor chemotherapy, poly(acrylic acid-co-methyl methacrylate) microparticles have been synthesized. Carboxylate containing monomers were included to complex therapeutic agents, specifically cisplatin. Microparticles were prepared by free radical emulsion polymerization in aqueous media. Particle diameter, zeta-potential, in vitro cytotoxicity, and in vivo acute toxicity were characterized for both cisplatin-loaded microparticles and unloaded microparticles. In vitro cytotoxicity and FT-IR were used to characterize cisplatin released from cisplatin-loaded microparticles. Acrylic acid feed mole fraction determined several key microparticle properties, including particle size, zeta-potential, and yield. A burst release of cisplatin (40%) in the first day was followed by a zero-order release phase. The interaction between cisplatin and microparticles allowed approximately 20% additional cisplatin release in the next five days. Cisplatin-loaded and unloaded microparticles are non-toxic (LC50>15 mM) to the cell line used in in vitro tests. Cisplatin released from cisplatin-loaded microparticles retained activity, but that activity was slightly lower than freshly prepared cisplatin. Other than a slight reduction in cisplatin activity, microparticles exhibited low in vivo acute toxicity (LD50>170 mg/kg), which suggests that this hydrogel particulate system and the hydrogel complexation mechanism should further be studied for drug delivery. |
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Authors:
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Xiaoliang Yan; Richard A Gemeinhart |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 106 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2006-01-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: Netherlands |
Other Details:
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Languages: eng Pagination: 198-208 Citation Subset: IM |
Affiliation:
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Department of Biopharmaceutical Sciences, University of Illinois, Chicago, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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chemistry,
pharmacology*,
toxicity Animals Antineoplastic Agents / administration & dosage*, chemistry Cell Survival / drug effects Cisplatin / administration & dosage*, chemistry Drug Carriers* Female Lethal Dose 50 Mice Microspheres NIH 3T3 Cells Polymethacrylic Acids / pharmacology*, toxicity Polymethyl Methacrylate / chemistry, pharmacology*, toxicity Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR15482/RR/NCRR NIH HHS; R03 EY014357/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Antineoplastic Agents; 0/Drug Carriers; 0/Polymethacrylic Acids; 0/poly(acrylic acid-co-methyl methacrylate); 15663-27-1/Cisplatin; 9003-01-4/carbopol 940; 9011-14-7/Polymethyl Methacrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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