Document Detail


Cisplatin as second-line chemotherapy in the treatment of advanced or recurrent leiomyosarcoma of the uterus. A phase II trial of the Gynecologic Oncology Group.
MedLine Citation:
PMID:  3953489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty patients with advanced or recurrent leiomyosarcoma of the uterus who failed prior chemotherapy were placed on study by the Gynecologic Oncology Group. One patient had insufficient data to permit analysis. Of the remaining 19, there was only one objective response to cisplatin 50 mg/m2 intravenously every 3 weeks. Although toxicity was tolerable, there is little evidence of drug activity in patients with leiomyosarcomas of the uterus when the drug is given as second-line chemotherapy in the dose and schedule tested.
Authors:
J T Thigpen; J A Blessing; G D Wilbanks
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  9     ISSN:  0277-3732     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-10     Completed Date:  1986-04-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Cisplatin / therapeutic use*
Drug Evaluation
Female
Humans
Leiomyosarcoma / drug therapy*
Middle Aged
Uterine Neoplasms / drug therapy*
Grant Support
ID/Acronym/Agency:
CA-12482/CA/NCI NIH HHS; CA-12534/CA/NCI NIH HHS; CA-13633/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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