Document Detail

Cisplatin as second-line chemotherapy in the treatment of advanced or recurrent leiomyosarcoma of the uterus. A phase II trial of the Gynecologic Oncology Group.
MedLine Citation:
PMID:  3953489     Owner:  NLM     Status:  MEDLINE    
Twenty patients with advanced or recurrent leiomyosarcoma of the uterus who failed prior chemotherapy were placed on study by the Gynecologic Oncology Group. One patient had insufficient data to permit analysis. Of the remaining 19, there was only one objective response to cisplatin 50 mg/m2 intravenously every 3 weeks. Although toxicity was tolerable, there is little evidence of drug activity in patients with leiomyosarcomas of the uterus when the drug is given as second-line chemotherapy in the dose and schedule tested.
J T Thigpen; J A Blessing; G D Wilbanks
Related Documents :
18521209 - Eortc group phase ii study of oral etoposide for pretreated soft tissue sarcoma.
22024039 - Multivariate prognostic study on node-positive gastric cancer: is tumor size a prognost...
12954119 - Chemotherapy tolerance after radioimmunotherapy with 90y-cc49 monoclonal antibody in pa...
17343329 - Vinorelbine/vp-16 (etoposide) in metastatic breast cancer: a phase ii study.
6683629 - An eortc phase ii study of vindesine in advanced prostate cancer.
21965769 - The prognostic role of lymphovascular invasion in urothelial-cell carcinoma of upper an...
3496749 - Thymic atrophy and regrowth in response to chemotherapy: ct evaluation.
15831269 - Staging for liver cancer.
11696619 - Risk factors for lymph node metastases and their prognostic significance in early gastr...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  9     ISSN:  0277-3732     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-10     Completed Date:  1986-04-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cisplatin / therapeutic use*
Drug Evaluation
Leiomyosarcoma / drug therapy*
Middle Aged
Uterine Neoplasms / drug therapy*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  ICRF-159 (razoxane) in patients with advanced adenocarcinoma of the endometrium. A Gynecologic Oncol...
Next Document:  Methyl-CCNU and methotrexate therapy in patients with advanced colorectal cancer after failure of 5-...