| Cisplatin augments FAS-mediated apoptosis through lipid rafts. | |
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MedLine Citation:
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PMID: 20651352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cisplatin is widely and effectively used for the treatment of various types of cancer. However, its biochemical mechanisms are still unelucidated. Previously, we reported that membrane sphingomyelin (SM) was important for FAS-mediated apoptosis through lipid raft function. In this study, we strikingly show that cisplatin combined with CH11 (anti-FAS antibody, IgM) was able to induce marked apoptosis in SM synthase-restored WR/Fas-SMS1 cells, but not in SM synthase-deficient WR/FAS-SM(-) cells. In addition, we demonstrated that membrane SM played an important role in cisplatin/CH11-induced apoptosis through the classical caspase-dependent pathway, mainly by enhancing the formation of FAS-associated signaling complexes. |
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Authors:
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Cheng-Ri Huang; Zhe-Xiong Jin; Lingli Dong; Xiao-Peng Tong; Sun Yue; Takafumi Kawanami; Toshioki Sawaki; Tomoyuki Sakai; Miyuki Miki; Haruka Iwao; Akio Nakajima; Yasufumi Masaki; Yoshihiko Fukushima; Masao Tanaka; Yoshimasa Fujita; Hideo Nakajima; Toshiro Okazaki; Hisanori Umehara |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 30 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2065-71 Citation Subset: IM |
Affiliation:
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Department of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD95
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physiology* Antineoplastic Agents / pharmacology* Apoptosis / drug effects* Caspase 3 / analysis Caspase 8 / analysis Cell Survival / drug effects Cisplatin / pharmacology* Fas-Associated Death Domain Protein / physiology Humans Membrane Microdomains / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Antineoplastic Agents; 0/FADD protein, human; 0/Fas-Associated Death Domain Protein; 15663-27-1/Cisplatin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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