Document Detail

Cisplatin application in pregnancy: first in vivo analysis of 7 patients.
MedLine Citation:
PMID:  21071993     Owner:  NLM     Status:  MEDLINE    
Cervical cancer in pregnancy is an oncologic challenge. Empirical cisplatin is recommended to prevent cancer progression until fetal maturity. Seven patients with cervical cancer in the second trimester decided to delay delivery together with neoadjuvant chemotherapy. After 2-4 cycles, caesarean section and radical hysterectomy were performed above 32 weeks of gestation. Synchronous samples from maternal blood, umbilical cord blood and amniotic fluid were taken. All patients delivered healthy babies. Cisplatin concentrations in umbilical cord and amniotic fluid were 31-65 and 13-42% of the maternal blood, respectively. This is the first series on in vivo cisplatin concentration in the fetomaternal compartment.
Simone Marnitz; Christhardt Köhler; Peter Oppelt; Alexander Schmittel; Giovanni Favero; Kati Hasenbein; Achim Schneider; Maurie Markman
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Publication Detail:
Type:  Journal Article     Date:  2010-11-12
Journal Detail:
Title:  Oncology     Volume:  79     ISSN:  1423-0232     ISO Abbreviation:  Oncology     Publication Date:  2010  
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Department of Radiooncology, Campus CCM and CVK, Charité - Universitätsmedizin Berlin, Berlin, Germany.
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MeSH Terms
Adenocarcinoma / drug therapy
Amniotic Fluid / metabolism
Antineoplastic Agents / blood,  metabolism*,  therapeutic use*
Carcinoma, Squamous Cell / drug therapy
Cesarean Section
Chemotherapy, Adjuvant
Cisplatin / blood,  metabolism*,  therapeutic use*
Fetal Blood / metabolism
Interdisciplinary Communication
Lymph Node Excision
Lymphatic Metastasis
Neoadjuvant Therapy / methods*
Neoplasm Staging
Pregnancy Complications, Neoplastic / blood,  drug therapy*,  metabolism
Pregnancy Trimester, Second
Radiotherapy, Adjuvant
Uterine Cervical Neoplasms / blood,  drug therapy*,  metabolism
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

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