| Cisplatin application in pregnancy: first in vivo analysis of 7 patients. | |
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MedLine Citation:
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PMID: 21071993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cervical cancer in pregnancy is an oncologic challenge. Empirical cisplatin is recommended to prevent cancer progression until fetal maturity. Seven patients with cervical cancer in the second trimester decided to delay delivery together with neoadjuvant chemotherapy. After 2-4 cycles, caesarean section and radical hysterectomy were performed above 32 weeks of gestation. Synchronous samples from maternal blood, umbilical cord blood and amniotic fluid were taken. All patients delivered healthy babies. Cisplatin concentrations in umbilical cord and amniotic fluid were 31-65 and 13-42% of the maternal blood, respectively. This is the first series on in vivo cisplatin concentration in the fetomaternal compartment. |
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Authors:
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Simone Marnitz; Christhardt Köhler; Peter Oppelt; Alexander Schmittel; Giovanni Favero; Kati Hasenbein; Achim Schneider; Maurie Markman |
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Publication Detail:
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Type: Journal Article Date: 2010-11-12 |
Journal Detail:
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Title: Oncology Volume: 79 ISSN: 1423-0232 ISO Abbreviation: Oncology Publication Date: 2010 |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0135054 Medline TA: Oncology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 72-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Radiooncology, Campus CCM and CVK, Charité - Universitätsmedizin Berlin, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy Adult Amniotic Fluid / metabolism Antineoplastic Agents / blood, metabolism*, therapeutic use* Carcinoma, Squamous Cell / drug therapy Cesarean Section Chemotherapy, Adjuvant Cisplatin / blood, metabolism*, therapeutic use* Female Fetal Blood / metabolism Humans Hysterectomy Interdisciplinary Communication Laparoscopy Lymph Node Excision Lymphatic Metastasis Neoadjuvant Therapy / methods* Neoplasm Staging Pregnancy Pregnancy Complications, Neoplastic / blood, drug therapy*, metabolism Pregnancy Trimester, Second Radiotherapy, Adjuvant Uterine Cervical Neoplasms / blood, drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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