| Cisapride: the problem of the heart. | |
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MedLine Citation:
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PMID: 10808885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cisapride has been used in the neonatal population as a first-line gastrointestinal prokinetic agent for managing feeding intolerance secondary to decreased gastrointestinal motility. Cisapride acts specifically at many levels of the gastrointestinal tract and has no central nervous system side effects. Recently, prolonged QT interval has been reported secondary to high-dose cisapride, and concerns regarding its use in premature infants have been raised. In response, Janssen-Ortho Inc. and Janssen Pharmaceutica, the manufacturers of cisapride in Canada and the U.S., have released safety information prohibiting the use of cisapride in premature infants. In light of the present evidence, it is imperative that NICUs that continue to prescribe cisapride for the management of feeding intolerance exercise vigilance in cardiac monitoring and recognize the importance of drug interactions that lead to elevated cisapride levels. |
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Authors:
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S S Premji; B Paes |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neonatal network : NN Volume: 18 ISSN: 0730-0832 ISO Abbreviation: Neonatal Netw Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-08-03 Completed Date: 2000-08-03 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8503921 Medline TA: Neonatal Netw Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 21-5 Citation Subset: N |
Affiliation:
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Hamilton Health Sciences Corporation, Ontario, Canada. Premji@exchangel.cmh.on.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Canada Cisapride / adverse effects*, contraindications* Drug Information Services Drug Interactions Drug Monitoring Gastrointestinal Agents / adverse effects*, contraindications* Humans Infant, Newborn Infant, Premature Long QT Syndrome / chemically induced* United States |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 81098-60-4/Cisapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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