Document Detail

Cisapride: the problem of the heart.
MedLine Citation:
PMID:  10808885     Owner:  NLM     Status:  MEDLINE    
Cisapride has been used in the neonatal population as a first-line gastrointestinal prokinetic agent for managing feeding intolerance secondary to decreased gastrointestinal motility. Cisapride acts specifically at many levels of the gastrointestinal tract and has no central nervous system side effects. Recently, prolonged QT interval has been reported secondary to high-dose cisapride, and concerns regarding its use in premature infants have been raised. In response, Janssen-Ortho Inc. and Janssen Pharmaceutica, the manufacturers of cisapride in Canada and the U.S., have released safety information prohibiting the use of cisapride in premature infants. In light of the present evidence, it is imperative that NICUs that continue to prescribe cisapride for the management of feeding intolerance exercise vigilance in cardiac monitoring and recognize the importance of drug interactions that lead to elevated cisapride levels.
S S Premji; B Paes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neonatal network : NN     Volume:  18     ISSN:  0730-0832     ISO Abbreviation:  Neonatal Netw     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-08-03     Completed Date:  2000-08-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8503921     Medline TA:  Neonatal Netw     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  N    
Hamilton Health Sciences Corporation, Ontario, Canada.
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MeSH Terms
Cisapride / adverse effects*,  contraindications*
Drug Information Services
Drug Interactions
Drug Monitoring
Gastrointestinal Agents / adverse effects*,  contraindications*
Infant, Newborn
Infant, Premature
Long QT Syndrome / chemically induced*
United States
Reg. No./Substance:
0/Gastrointestinal Agents; 81098-60-4/Cisapride

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