Document Detail

Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
MedLine Citation:
PMID:  10608215     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride p.o. or placebo preoperatively to 64 ASA 1-2 ambulatory surgical patients. Following induction of anesthesia we measured volume and pH of residual gastric contents, using blind aspiration through an orogastric tube. Parametric data were analysed using unpaired, one tail Students' t test. Non-parametric data were analysed using Fishers Exact test and Chi square analysis. Statistical significance was accepted at the probability level of < 0.05. RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). Data shown are mean (+/- SD). The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). The proportions of patients with pH < 2.5 was also similar in the cisapride and placebo groups (21 of 25, and 20 of 21 patients respectively, P=0.2). CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. Its use in this setting is of no apparent clinical benefit.
A Lydon; C Murray; J McGinley; R Plant; F Duggan; G Shorten
Related Documents :
6323335 - Ranitidine, cimetidine and antacids in the prevention of recurrence after healed duoden...
16377775 - Ineffectiveness of lactobacillus johnsonii la1 for prophylaxis of postoperative recurre...
1752455 - Healing and prevention of relapse of reflux oesophagitis by cisapride.
19201775 - Adalimumab for the treatment of fistulas in patients with crohn's disease.
18692345 - The long-term outcomes of percutaneous therapy for renal artery fibromuscular dysplasia.
22124425 - Circumferential cervical surgery : to stage or not to stage?
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  46     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1181-4     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ambulatory Surgical Procedures*
Double-Blind Method
Gastrointestinal Contents / chemistry
Hemodynamics / drug effects
Hydrogen-Ion Concentration
Preoperative Care*
Prospective Studies
Stomach / anatomy & histology,  drug effects*,  metabolism
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Airway management of a child after tracheal resection.
Next Document:  Oxygen concentrators: a primary oxygen supply source.