Document Detail


Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
MedLine Citation:
PMID:  10608215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride p.o. or placebo preoperatively to 64 ASA 1-2 ambulatory surgical patients. Following induction of anesthesia we measured volume and pH of residual gastric contents, using blind aspiration through an orogastric tube. Parametric data were analysed using unpaired, one tail Students' t test. Non-parametric data were analysed using Fishers Exact test and Chi square analysis. Statistical significance was accepted at the probability level of < 0.05. RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). Data shown are mean (+/- SD). The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). The proportions of patients with pH < 2.5 was also similar in the cisapride and placebo groups (21 of 25, and 20 of 21 patients respectively, P=0.2). CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. Its use in this setting is of no apparent clinical benefit.
Authors:
A Lydon; C Murray; J McGinley; R Plant; F Duggan; G Shorten
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  46     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-24     Completed Date:  2000-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1181-4     Citation Subset:  IM    
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital and University College Cork, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Ambulatory Surgical Procedures*
Cisapride*
Double-Blind Method
Female
Gastrointestinal Contents / chemistry
Hemodynamics / drug effects
Humans
Hydrogen-Ion Concentration
Male
Preoperative Care*
Prospective Studies
Stomach / anatomy & histology,  drug effects*,  metabolism
Chemical
Reg. No./Substance:
81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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