Document Detail


Cis-vaccenic acid and the Framingham risk score predict chronic kidney disease: the multi-ethnic study of atherosclerosis (MESA).
MedLine Citation:
PMID:  22417701     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Data on the associations of fatty acids with chronic kidney disease (CKD) are sparse.
MATERIALS AND METHODS: We performed a cross-sectional study of 2792 men and women from the MESA cohort of African-American, Caucasian, Chinese and Hispanic adults without known cardiovascular disease. Plasma phospholipid fatty acid proportions were associated with estimated glomerular filtration rate (eGFR) and the albumin/creatinine ratio.
RESULTS: Cis-vaccenic acid (18:1n-7), adjusted for other fatty acids using multivariate logistic regression (CI: 1.0-1.4), and step-wise logistic regression (CI: 1.02-1.42), was positively associated with reduced eGFR. The Framingham Risk Score, when adjusting for fatty acid proportions and demographic factors, was positively associated with CKD as measured by the eGFR and the albumin/creatinine ratio.
DISCUSSION AND CONCLUSIONS: Plasma phospholipid proportions of the 18 carbon monounsaturated cis-vaccenic acid {18:1n-7}) and the Framingham Risk Score are associated with kidney function. The potential role of 18:1n-7 in the development of CKD warrants further investigation.
Authors:
Robert Block; Lisa Kakinami; Scott Liebman; Gregory C Shearer; Holly Kramer; Michael Tsai
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-13
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  86     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-30     Completed Date:  2012-10-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  175-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Community and Preventive Medicine, Division of Epidemiology, the University of Rochester School of Medicine, Rochester, NY 14642, USA. robert_block@urmc.rochester.edu
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Aged
Asian Americans
Atherosclerosis / complications*
Creatinine / blood
Cross-Sectional Studies
European Continental Ancestry Group
Female
Glomerular Filtration Rate
Hispanic Americans
Humans
Kidney Failure, Chronic / ethnology*,  etiology,  physiopathology*
Logistic Models
Male
Middle Aged
Oleic Acids / blood*
Risk Factors
Grant Support
ID/Acronym/Agency:
KL2 RR024136/RR/NCRR NIH HHS; KL2 RR024136-04/RR/NCRR NIH HHS; KL2 RR024136-05/RR/NCRR NIH HHS; KL2 RR024136-06/RR/NCRR NIH HHS; KL2RR024136/RR/NCRR NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; P20RR016479/RR/NCRR NIH HHS; R01HL071933/HL/NHLBI NIH HHS; R21 HL102582-01/HL/NHLBI NIH HHS; R21 HL102582-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Oleic Acids; 506-17-2/cis-vaccenic acid; 60-27-5/Creatinine
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